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Table 1 Hit rate of TCPTP activators after removal of false positives due to compound interference.

From: Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase

Library Compounds Primary hits Confirmed activators
Tripos 6000 5 1
ChemDiv 25000 23 1
ChemBridge 30000 167 0
Microsource Spectrum 2000 16 2
Sigma Lopac 1280 2 2
Total 64280 213 6
  1. Primary hits were individually picked from the libraries and screened again in HTS. Reproducing hits were confirmed with different concentrations resulting in total of six validated TCPTP activators.