Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase

Table 1 Hit rate of TCPTP activators after removal of false positives due to compound interference.

Library	Compounds	Primary hits	Confirmed activators
Tripos	6000	5	1
ChemDiv	25000	23	1
ChemBridge	30000	167	0
Microsource Spectrum	2000	16	2
Sigma Lopac	1280	2	2
Total	64280	213	6

Primary hits were individually picked from the libraries and screened again in HTS. Reproducing hits were confirmed with different concentrations resulting in total of six validated TCPTP activators.

ISSN: 1471-2407