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Table 3 Results of the 5 separate Cox regression analyses to evaluate the prognostic factors associated with the risk of locoregional recurrence, contralateral breast cancer, metastases or 2nd cancer other than breast

From: Separate and combined analysis of successive dependent outcomes after breast-conservation surgery: recurrence, metastases, second cancer and death

Characteristic Locoregional recurrences Contralateral breast cancer Distant metastases 2nd primary cancer other than breast Breast cancer death
  RR
(95% CI)
p RR
(95% CI)
P RR
(95% CI)
P RR
(95% CI)
p RR
(95% CI)
p
Histological size of the tumor (for 1 mm increase) 1.02
(0.99-1.06)
0.17 1.02
(0.97-1.06)
0.54 1.02
(1.00-1.05)
0.08 1.01
(0.93-1.10)
0.75 1.02
(0.99-1.05)
0.27
Extensive intraductal component (EIC)           
   - No (ref) 1   1   1   --   1  
   - Yes 3.34
(0.89-12.5)
0.07 0.99
(0.13-7.46)
1.00 1.55
(0.34-7.06)
0.57 -- -- 1.43
(0.20-10.8)
0.73
Grade           
   - Grade1(ref) 1   1   1   1   1  
   - Grade 2 1.84
(1.11-3.07)
0.02 1.45
(0.78-2.70)
0.24 2.68
(1.58-4.53)
< 0.001 0.68
(0.23-2.01)
0.48 3.64
(1.74-7.60)
< 0.001
   - Grade 3 2.12
(1.17-3.84)
0.01 0.94
(0.40-2.21)
0.88 3.39
(1.91-6.02)
< 0.001 1.32
(0.37-4.75)
0.67 5.54
(2.58-11.9)
< 0.001
# positive nodes           
   - 0 (ref) 1   1   1   --   1  
   - 1-3 2.60
(1.30-5.19)
0.007 1.17
(0.34-3.97)
0.81 2.41
(1.29-4.47)
0.006 -- -- 2.92
(1.50-5.68)
0.002
   - ≥4 4.40
(1.80-10.7)
0.001 0.66
(0.13-3.45)
0.62 6.91
(3.41-14.0)
< 0.001 -- -- 8.03
(3.71-17.4)
< 0.001
Lympho-vascular invasion           
   - No (ref) 1   1   1   1   1  
   - Yes 1.29
(0.84-1.98)
0.24 0.41
(0.19-0.90)
0.03 1.47
(1.04-2.08)
0.03 1.40
(0.51-3.83)
0.51 1.27
(0.87-1.91)
0.26
Surgical excision margin status           
   - Clear (ref) 1   1   1   1   1  
   - Invasion 0.95
(0.64-1.43)
0.81 2.36
(1.40-3.98)
0.001 1.05
(0.74-1.48)
0.78 0.57
(0.19-1.73)
0.32 1.12
(0.75-1.67)
0.59
Progesterone receptor status           
   -Positive(ref) 1   1   1   1   1  
   - Negative 1.26
(0.84-1.88)
0.26 1.21
(0.70-2.09)
0.49 1.32
(0.93-1.86)
0.12 0.33
(0.11-1.03)
0.06 1.90
(1.26-2.87)
0.002
Treatment combination           
   - Radiotherapy (ref) 1   1   1   --   1  
   - Radio- and chemotherapy 0.23
(0.11-0.50)
< 0.001 1.22
(0.33-4.55)
0.77 0.52
(0.27-1.02)
0.06 -- -- 0.56
(0.27-1.16)
0.12
   - Radio- and hormonal therapy 0.35
(0.16-0.77)
0.009 0.78
(0.21-2.91)
0.71 0.59
(0.30-1.13)
0.11 -- -- 0.48
(0.24-0.99)
0.05
   - Radio- and chemo- and hormonal therapy 0.06
(0.01-0.49)
0.008 0.74
(0.07-7.60)
0.80 0.33
(0.11-0.99)
0.05 -- -- 0.28
(0.07-1.06)
0.06
  1. -- variables not included in the model