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Table 3 Results of the 5 separate Cox regression analyses to evaluate the prognostic factors associated with the risk of locoregional recurrence, contralateral breast cancer, metastases or 2nd cancer other than breast

From: Separate and combined analysis of successive dependent outcomes after breast-conservation surgery: recurrence, metastases, second cancer and death

Characteristic

Locoregional recurrences

Contralateral breast cancer

Distant metastases

2nd primary cancer other than breast

Breast cancer death

 

RR

(95% CI)

p

RR

(95% CI)

P

RR

(95% CI)

P

RR

(95% CI)

p

RR

(95% CI)

p

Histological size of the tumor (for 1 mm increase)

1.02

(0.99-1.06)

0.17

1.02

(0.97-1.06)

0.54

1.02

(1.00-1.05)

0.08

1.01

(0.93-1.10)

0.75

1.02

(0.99-1.05)

0.27

Extensive intraductal component (EIC)

          

   - No (ref)

1

 

1

 

1

 

--

 

1

 

   - Yes

3.34

(0.89-12.5)

0.07

0.99

(0.13-7.46)

1.00

1.55

(0.34-7.06)

0.57

--

--

1.43

(0.20-10.8)

0.73

Grade

          

   - Grade1(ref)

1

 

1

 

1

 

1

 

1

 

   - Grade 2

1.84

(1.11-3.07)

0.02

1.45

(0.78-2.70)

0.24

2.68

(1.58-4.53)

< 0.001

0.68

(0.23-2.01)

0.48

3.64

(1.74-7.60)

< 0.001

   - Grade 3

2.12

(1.17-3.84)

0.01

0.94

(0.40-2.21)

0.88

3.39

(1.91-6.02)

< 0.001

1.32

(0.37-4.75)

0.67

5.54

(2.58-11.9)

< 0.001

# positive nodes

          

   - 0 (ref)

1

 

1

 

1

 

--

 

1

 

   - 1-3

2.60

(1.30-5.19)

0.007

1.17

(0.34-3.97)

0.81

2.41

(1.29-4.47)

0.006

--

--

2.92

(1.50-5.68)

0.002

   - ≥4

4.40

(1.80-10.7)

0.001

0.66

(0.13-3.45)

0.62

6.91

(3.41-14.0)

< 0.001

--

--

8.03

(3.71-17.4)

< 0.001

Lympho-vascular invasion

          

   - No (ref)

1

 

1

 

1

 

1

 

1

 

   - Yes

1.29

(0.84-1.98)

0.24

0.41

(0.19-0.90)

0.03

1.47

(1.04-2.08)

0.03

1.40

(0.51-3.83)

0.51

1.27

(0.87-1.91)

0.26

Surgical excision margin status

          

   - Clear (ref)

1

 

1

 

1

 

1

 

1

 

   - Invasion

0.95

(0.64-1.43)

0.81

2.36

(1.40-3.98)

0.001

1.05

(0.74-1.48)

0.78

0.57

(0.19-1.73)

0.32

1.12

(0.75-1.67)

0.59

Progesterone receptor status

          

   -Positive(ref)

1

 

1

 

1

 

1

 

1

 

   - Negative

1.26

(0.84-1.88)

0.26

1.21

(0.70-2.09)

0.49

1.32

(0.93-1.86)

0.12

0.33

(0.11-1.03)

0.06

1.90

(1.26-2.87)

0.002

Treatment combination

          

   - Radiotherapy (ref)

1

 

1

 

1

 

--

 

1

 

   - Radio- and chemotherapy

0.23

(0.11-0.50)

< 0.001

1.22

(0.33-4.55)

0.77

0.52

(0.27-1.02)

0.06

--

--

0.56

(0.27-1.16)

0.12

   - Radio- and hormonal therapy

0.35

(0.16-0.77)

0.009

0.78

(0.21-2.91)

0.71

0.59

(0.30-1.13)

0.11

--

--

0.48

(0.24-0.99)

0.05

   - Radio- and chemo- and hormonal therapy

0.06

(0.01-0.49)

0.008

0.74

(0.07-7.60)

0.80

0.33

(0.11-0.99)

0.05

--

--

0.28

(0.07-1.06)

0.06

  1. -- variables not included in the model