Figure 4

Treatment with sunitinib decreases circulating monocytes in all treated patients, irrespective of their clinical response to treatment. A) Monocytes decrease during repeated exposure to sunitinib. However, increased values are measured after the 2-weeks washout interval of sunitinib. B) Patients were grouped according to PFS above or below the median. In both groups, monocyte counts decrease significantly from baseline to day 28 [P = 0.0006 (below median); P < 0.0001 (above median)]. However, monocyte counts at day 1 and 28 remained similar between both groups [P = 0.5701 (day 1), P = 0.3006 (day 28), respectively].