Figure 3

CEC display a characteristic response to treatment with sunitinib. A) Characteristic changes of CEC counts are depicted in 13 patients with repeated measures for the duration of 238 days. Curve shows a marked increase within 28 days, followed by decreased CEC counts to a basal level. Bars show mean standard error mean. B) Patients were grouped according to their PFS above or below the median. CEC measured at baseline and after 28 days of treatment with sunitinib are depicted for both groups. In patients with PFS above the median mean CEC values increased significantly from baseline 40 ± 41 CEC/ml to 111 ± 61 (P = 0.0109) at day 28. However, in patients with PFS below the median, the increase from 53 ± 45 to 69 ± 61 CEC/ml remained insignificant (P = 0.1848).