The Colorectal cancer disease-specific transcriptome may facilitate the discovery of more biologically and clinically relevant information

Table 3 Pathway analysis from Colorectal DSA

Pathways	Number of genes	p value
Biosynthesis of steroids	17	1.26×10^-07
Cell cycle	50	1.24×10^-05
DNA polymerase	16	0.000153
Fatty acid metabolism	17	0.0119
Folate biosynthesis	18	0.000637
Fructose and mannose metabolism	18	0.00818
Glycerophospholipid metabolism	21	0.0271
Glycolysis Gluconeogenesis	17	0.00872
Insulin signaling pathway	44	0.0427
Oxidative phosphorylation	46	2.98×10^-09
Proteasome	15	1.50×10^-08
Purine metabolism	59	8.06×10^-07
Pyrimidine metabolism	43	3.15×10^-08
Starch and sucrose metabolism	26	0.000391
Tryptophan metabolism	27	0.00542
Valine, leucine and isoleucine degradation	19	0.00915

Based on the complete content of the Colorectal DSA for 3713 genes passing flags, 1.3-fold change and t-test in the sensitive experiment. Displayed are the numbers of genes from a given pathway that are detected, differentially expressed and also passing a t-test filter. Pathways selected that are statistically significant based on hypergeometric statistics.

ISSN: 1471-2407