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Figure 3 | BMC Cancer

Figure 3

From: Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase

Figure 3

In vitro NAMPT enzyme assays. A: kcat values for wild type NAMPT (NAMPTwt) and NAMPT with K342R, H191R and D93del mutations respectively. Statistical significance compared with NAMPTwt: **: <0.0005, ***: <0.0001. B: IC50 values of APO866 for in vitro inhibition of NAMPTwt and NAMPTH191R. The Y-axis is logarithmic. Statistical significance compared with NAMPTwt: *: <0,05. Error bars indicate SEM.

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BMC Cancer

ISSN: 1471-2407

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