TY - JOUR AU - Wechsler-Reya, R. AU - Scott, M. P. PY - 2001 DA - 2001// TI - The developmental biology of brain tumors JO - Annu Rev Neurosci VL - 24 UR - https://doi.org/10.1146/annurev.neuro.24.1.385 DO - 10.1146/annurev.neuro.24.1.385 ID - Wechsler-Reya2001 ER - TY - JOUR AU - Ellison, D. PY - 2002 DA - 2002// TI - Classifying the medulloblastoma: insights from morphology and molecular genetics JO - Neuropathol Appl Neurobiol VL - 28 UR - https://doi.org/10.1046/j.1365-2990.2002.00419.x DO - 10.1046/j.1365-2990.2002.00419.x ID - Ellison2002 ER - TY - JOUR AU - Pomeroy, S. L. AU - Tamayo, P. AU - Gaasenbeek, M. AU - Sturla, L. M. AU - Angelo, M. AU - McLaughlin, M. E. AU - Kim, J. Y. AU - Goumnerova, L. C. AU - Black, P. M. AU - Lau, C. AU - Allen, J. C. AU - Zagzag, D. AU - Olson, J. M. AU - Curran, T. AU - Wetmore, C. AU - Biegel, J. A. AU - Poggio, T. AU - Mukherjee, S. AU - Rifkin, R. AU - Califano, A. AU - Stolovitzky, G. AU - Louis, D. N. AU - Mesirov, J. P. AU - Lander, E. S. AU - Golub, T. R. PY - 2003 DA - 2003// TI - Prediction of central nervous system embryonal tumour outcome based on gene expression JO - Nature VL - 415 UR - https://doi.org/10.1038/415436a DO - 10.1038/415436a ID - Pomeroy2003 ER - TY - JOUR AU - Raffel, C. AU - Jenkins, R. B. AU - Frederick, L. AU - Hebrink, D. AU - Alderete, B. AU - Fults, D. W. AU - James, C. D. PY - 1997 DA - 1997// TI - Sporadic medulloblastomas contain PTCH mutations JO - Cancer Res VL - 57 ID - Raffel1997 ER - TY - JOUR AU - Pietsch, T. AU - Waha, A. AU - Koch, A. AU - Kraus, J. AU - Albrecht, S. AU - Tonn, J. AU - Sörensen, N. AU - Berthold, F. AU - Henk, B. AU - Schmandt, N. AU - Wolf, H. K. AU - von Deimling, A. AU - Wainwright, B. AU - Chenevix-Trench, G. AU - Wiestler, O. D. AU - Wicking, C. PY - 1997 DA - 1997// TI - Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched JO - Cancer Res VL - 57 ID - Pietsch1997 ER - TY - JOUR AU - Echelard, Y. AU - Epstein, D. J. AU - St-Jacques, B. AU - Shen, L. AU - Mohler, J. AU - McMahon, J. A. AU - McMahon, A. P. PY - 1993 DA - 1993// TI - Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity JO - Cell VL - 75 UR - https://doi.org/10.1016/0092-8674(93)90627-3 DO - 10.1016/0092-8674(93)90627-3 ID - Echelard1993 ER - TY - JOUR AU - Roessler, E. AU - Belloni, E. AU - Gaudenz, K. AU - Jay, P. AU - Berta, P. AU - Scherer, S. W. AU - Tsui, L. C. AU - Muenke, M. PY - 1996 DA - 1996// TI - Mutations in the human Sonic Hedgehog gene cause holoprosencephaly JO - Nat Genet VL - 14 UR - https://doi.org/10.1038/ng1196-357 DO - 10.1038/ng1196-357 ID - Roessler1996 ER - TY - JOUR AU - Dahmane, N. AU - Ruiz i Altaba, A. PY - 1999 DA - 1999// TI - Sonic hedgehog regulates the growth and patterning of the cerebellum JO - Development VL - 126 ID - Dahmane1999 ER - TY - JOUR AU - Palma, V. AU - Lim, D. A. AU - Dahmane, N. AU - Sánchez, P. AU - Brionne, T. C. AU - Herzberg, C. D. AU - Gitton, Y. AU - Carleton, A. AU - Alvarez-Buylla, A. AU - Ruiz i Altaba, A. PY - 2005 DA - 2005// TI - Sonic hedgehog controls stem cell behavior in the postnatal and adult brain JO - Development VL - 132 UR - https://doi.org/10.1242/dev.01567 DO - 10.1242/dev.01567 ID - Palma2005 ER - TY - JOUR AU - Goodrich, L. V. AU - Milenkovic, L. AU - Higgins, K. M. AU - Scott, M. P. PY - 1997 DA - 1997// TI - Altered neural cell fates and medulloblastoma in mouse patched mutants JO - Science VL - 277 UR - https://doi.org/10.1126/science.277.5329.1109 DO - 10.1126/science.277.5329.1109 ID - Goodrich1997 ER - TY - JOUR AU - Barakat, M. T. AU - Humke, E. W. AU - Scott, M. P. PY - 2010 DA - 2010// TI - : Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer JO - Trends Mol Med VL - 16 UR - https://doi.org/10.1016/j.molmed.2010.05.003 DO - 10.1016/j.molmed.2010.05.003 ID - Barakat2010 ER - TY - JOUR AU - Hahn, H. AU - Christiansen, J. AU - Wicking, C. AU - Zaphiropoulos, P. G. AU - Chidambaram, A. AU - Gerrard, B. AU - Vorechovsky, I. AU - Bale, A. E. AU - Toftgard, R. AU - Dean, M. AU - Wainwright, B. PY - 1996 DA - 1996// TI - A mammalian patched homolog is expressed in target tissues of sonic hedgehog and maps to a region associated with developmental abnormalities JO - J Biol Chem VL - 271 UR - https://doi.org/10.1074/jbc.271.21.12125 DO - 10.1074/jbc.271.21.12125 ID - Hahn1996 ER - TY - JOUR AU - Johnson, R. L. AU - Rothman, A. L. AU - Xie, J. AU - Goodrich, L. V. AU - Bare, J. W. AU - Bonifas, J. M. AU - Quinn, A. G. AU - Myers, R. M. AU - Cox, D. R. AU - Epstein, E. H. AU - Scott, M. P. PY - 1996 DA - 1996// TI - Human homolog of patched, a candidate gene for the basal cell nevus syndrome JO - Science VL - 272 UR - https://doi.org/10.1126/science.272.5268.1668 DO - 10.1126/science.272.5268.1668 ID - Johnson1996 ER - TY - JOUR AU - Ruiz i Altaba, A. AU - Palma, V. AU - Dahmane, N. PY - 2002 DA - 2002// TI - Hedgehog-Gli signaling and the growth of the brain JO - Nat Rev Neurosci VL - 3 UR - https://doi.org/10.1038/nrn704 DO - 10.1038/nrn704 ID - Ruiz i Altaba2002 ER - TY - JOUR AU - Dellovade, T. AU - Romer, J. T. AU - Curran, T. AU - Rubin, L. L. PY - 2006 DA - 2006// TI - The hedgehog pathway and neurological disorders JO - Annu Rev Neurosci VL - 29 UR - https://doi.org/10.1146/annurev.neuro.29.051605.112858 DO - 10.1146/annurev.neuro.29.051605.112858 ID - Dellovade2006 ER - TY - JOUR AU - Cohen, M. M. PY - 2003 DA - 2003// TI - The hedgehog signaling network JO - Am J Med Genet A VL - 123A UR - https://doi.org/10.1002/ajmg.a.20495 DO - 10.1002/ajmg.a.20495 ID - Cohen2003 ER - TY - JOUR AU - Hooper, J. E. AU - Scott, M. P. PY - 2005 DA - 2005// TI - Communicating with Hedgehogs JO - Nat Rev Mol Cell Biol VL - 6 UR - https://doi.org/10.1038/nrm1622 DO - 10.1038/nrm1622 ID - Hooper2005 ER - TY - JOUR AU - Kinzler, K. W. AU - Vogelstein, B. PY - 1990 DA - 1990// TI - The GLI gene encodes a nuclear protein which binds specific sequences in the human genome JO - Mol Cell Biol VL - 10 UR - https://doi.org/10.1128/MCB.10.2.634 DO - 10.1128/MCB.10.2.634 ID - Kinzler1990 ER - TY - JOUR AU - Agren, M. AU - Kogerman, P. AU - Kleman, M. I. AU - Wessling, M. AU - Toftgård, R. PY - 2004 DA - 2004// TI - Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site JO - Gene VL - 330 UR - https://doi.org/10.1016/j.gene.2004.01.010 DO - 10.1016/j.gene.2004.01.010 ID - Agren2004 ER - TY - JOUR AU - Mas, C. AU - Ruiz i Altaba, A. PY - 2010 DA - 2010// TI - Small molecule modulation of HH-GLI signaling: current leads, trials and tribulations JO - Biochem Pharmacol VL - 80 UR - https://doi.org/10.1016/j.bcp.2010.04.016 DO - 10.1016/j.bcp.2010.04.016 ID - Mas2010 ER - TY - JOUR AU - Li, W. AU - Ohlmeyer, J. T. AU - Lane, M. E. AU - Kalderon, D. PY - 1995 DA - 1995// TI - Function of protein kinase A in HH signal transduction and Drosophila imaginal disc development JO - Cell VL - 80 UR - https://doi.org/10.1016/0092-8674(95)90509-X DO - 10.1016/0092-8674(95)90509-X ID - Li1995 ER - TY - JOUR AU - Hammerschmidt, M. AU - Bitgood, M. J. AU - McMahon, A. PY - 1996 DA - 1996// TI - Protein kinase A is as common negative regulator of SHH signaling in the vertebrate embryo JO - Genes Dev VL - 10 UR - https://doi.org/10.1101/gad.10.6.647 DO - 10.1101/gad.10.6.647 ID - Hammerschmidt1996 ER - TY - JOUR AU - Epstein, D. J. AU - Marti, E. AU - Scott, M. P. AU - McMahon, A. P. PY - 1996 DA - 1996// TI - Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved SHH signaling pathway JO - Development VL - 122 ID - Epstein1996 ER - TY - JOUR AU - Miyata, A. AU - Arimura, A. AU - Dahl, R. R. AU - Minamino, N. AU - Uehara, A. AU - Jiang, L. AU - Culler, M. D. AU - Coy, D. H. PY - 1989 DA - 1989// TI - Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells JO - Biochem Biophys Res Commun VL - 164 UR - https://doi.org/10.1016/0006-291X(89)91757-9 DO - 10.1016/0006-291X(89)91757-9 ID - Miyata1989 ER - TY - JOUR AU - Nicot, A. AU - DiCicco-Bloom, E. PY - 2001 DA - 2001// TI - Regulation of neuroblast mitosis is determined by PACAP receptor isoform expression JO - Proc Natl Acad Sci USA VL - 98 UR - https://doi.org/10.1073/pnas.071465398 DO - 10.1073/pnas.071465398 ID - Nicot2001 ER - TY - JOUR AU - Nicot, A. AU - Lelievre, V. AU - Tam, J. AU - Waschek, J. A. AU - DiCicco-Bloom, E. PY - 2002 DA - 2002// TI - Pituitary adenylate cyclase-activating polypeptide and sonic hedgehog interact to control cerebellar granule precursor cell proliferation JO - J Neurosci VL - 22 ID - Nicot2002 ER - TY - JOUR AU - Vaudry, D. AU - Gonzalez, B. J. AU - Basille, M. AU - Fournier, A. AU - Vaudry, H. PY - 1999 DA - 1999// TI - Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rat cerebellar cortex during development JO - Proc Natl Acad Sci USA VL - 96 UR - https://doi.org/10.1073/pnas.96.16.9415 DO - 10.1073/pnas.96.16.9415 ID - Vaudry1999 ER - TY - JOUR AU - Vaudry, D. AU - Gonzalez, B. J. AU - Basille, M. AU - Yon, L. AU - Fournier, A. AU - Vaudry, H. PY - 2000 DA - 2000// TI - Pituitary adenylate cyclase-activating polypeptide and its receptors: from structure to functions JO - Pharmacol Rev VL - 52 ID - Vaudry2000 ER - TY - JOUR AU - Pantaloni, C. AU - Brabet, P. AU - Bilanges, B. AU - Dumuis, A. AU - Houssami, S. AU - Spengler, D. AU - Bockaert, J. AU - Journot, L. PY - 1996 DA - 1996// TI - Alternative Splicing in the N-Terminal Extracellular Domain of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptor Modulates Receptor Selectivity and Relative Potencies of PACAP-27 and PACAP-38 in Phospholipase C Activation JO - J Biol Chem VL - 271 UR - https://doi.org/10.1074/jbc.271.36.22146 DO - 10.1074/jbc.271.36.22146 ID - Pantaloni1996 ER - TY - JOUR AU - Straub, S. G. AU - Sharp, G. W. PY - 1996 DA - 1996// TI - A Wortmannin-Sensitive Signal Transduction Pathyway Involved in the Stimulation of Insulin Release by Vasoactive Intestinal Polypeptide and Pituitary Adenylate Cyclase-Activating Polypeptide JO - J Biol Chem VL - 271 UR - https://doi.org/10.1074/jbc.271.3.1660 DO - 10.1074/jbc.271.3.1660 ID - Straub1996 ER - TY - JOUR AU - SW, K. o. h. PY - 1991 DA - 1991// TI - Signal Transduction Through the Vasoactive Intestinal Peptide Receptor Stimulates Phosphorylation of the Kinase pp60c-Src JO - Biochem Biophys Res Commun VL - 174 UR - https://doi.org/10.1016/0006-291X(91)91437-H DO - 10.1016/0006-291X(91)91437-H ID - SW1991 ER - TY - JOUR AU - Villalba, M. AU - Bockaert, J. AU - Journot, L. PY - 1997 DA - 1997// TI - Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP-38) Protects Cerebellar Granule Neurons from Apoptosis by Activating the Mitogen-Activated Protein Kinase (MAP Kinase) Pathway JO - J Neurosci VL - 17 ID - Villalba1997 ER - TY - JOUR AU - Barrie, A. F. AU - Clohessy, A. M. AU - Buensuceso, C. S. AU - Rogers, M. V. AU - Allen, J. M. PY - 1997 DA - 1997// TI - Pituitary Adenylyl Cyclase-Activating Peptide Stimulates Extracellular Signal-RegulatedKinase 1 or 2 (ERK1/2) Activity in In Ras-Independent, Mitogen-Activated Protein Kinase/ERK Kinase1 or 2-Dependent Manner in PC12 Cells JO - J Biol Chem VL - 272 UR - https://doi.org/10.1074/jbc.272.32.19666 DO - 10.1074/jbc.272.32.19666 ID - Barrie1997 ER - TY - JOUR AU - Lelievre, V. AU - Pineau, N. AU - Du, J. AU - C-H, W. e. n. AU - T.B, N. g. u. y. e. n. AU - Janet, J. AU - J-M, M. u. l. l. e. r. AU - JA, W. a. s. c. h. e. k. PY - 1998 DA - 1998// TI - Differential Effects of Peptide Histidine Isoleucine (PHI) and Related Peptides on Stimulation and Suppression on Neuroblastoma Cell Proliferation:A Novel VIP-Independent Action of PHI via MAP Kinase JO - J Biological Chemistry VL - 273 UR - https://doi.org/10.1074/jbc.273.31.19685 DO - 10.1074/jbc.273.31.19685 ID - Lelievre1998 ER - TY - JOUR AU - Traiffort, E. AU - Charytoniuk, D. AU - Watroba, L. AU - Faure, H. AU - Sales, N. AU - Ruat, M. PY - 1999 DA - 1999// TI - Discrete localizations of hedgehog signalling components in the developing and adult rat nervous system JO - Eur J Neurosci VL - 11 UR - https://doi.org/10.1046/j.1460-9568.1999.00777.x DO - 10.1046/j.1460-9568.1999.00777.x ID - Traiffort1999 ER - TY - JOUR AU - Lelievre, V. AU - Seksenyan, A. AU - Nobuta, H. AU - Yong, W. H. AU - Chhith, S. AU - Niewiadomski, P. AU - Cohen, J. R. AU - Dong, H. AU - Flores, A. AU - Liau, L. M. AU - Kornblum, H. I. AU - Scott, M. P. AU - Waschek, J. A. PY - 2008 DA - 2008// TI - Disruption Of The PACAP Gene Promotes Medulloblastoma In PTC1 Mutant Mice JO - Develop Biol VL - 313 UR - https://doi.org/10.1016/j.ydbio.2007.10.031 DO - 10.1016/j.ydbio.2007.10.031 ID - Lelievre2008 ER - TY - JOUR AU - Donehower, L. A. AU - Harvey, M. AU - Slagle, B. L. AU - McArthur, M. J. AU - Montgomery, C. A. AU - Butel, J. S. AU - Bradley, A. PY - 1992 DA - 1992// TI - Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours JO - Nature VL - 356 UR - https://doi.org/10.1038/356215a0 DO - 10.1038/356215a0 ID - Donehower1992 ER - TY - JOUR AU - Wetmore, C. AU - Eberhart, D. E. AU - Curran, T. PY - 2001 DA - 2001// TI - Loss of p53 but not ARF accelerates medulloblastoma in mice heterozygous for patched JO - Cancer Res VL - 61 ID - Wetmore2001 ER - TY - JOUR AU - Zhao, H. AU - Ayrault, O. AU - Zindy, F. AU - Kim, J. H. AU - Roussel, M. F. PY - 2008 DA - 2008// TI - Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development JO - Genes Dev VL - 22 UR - https://doi.org/10.1101/gad.1636408 DO - 10.1101/gad.1636408 ID - Zhao2008 ER - TY - JOUR AU - Sasai, K. AU - Romer, J. T. AU - Lee, Y. AU - Finkelstein, D. AU - Fuller, C. AU - McKinnon, P. J. AU - Curran, T. PY - 2006 DA - 2006// TI - Shh Pathway Activity Is Down-Regulated in Cultured Medulloblastoma Cells JO - Implications for Preclinical Studies Cancer Res VL - 66 ID - Sasai2006 ER - TY - JOUR AU - Chen, J. K. AU - Taipale, J. AU - Young, K. E. AU - Maiti, T. AU - Beachy, P. A. PY - 2002 DA - 2002// TI - Small molecule modulation of Smoothened activity JO - Proc Natl Acad Sci USA VL - 99 UR - https://doi.org/10.1073/pnas.182542899 DO - 10.1073/pnas.182542899 ID - Chen2002 ER - TY - JOUR AU - Wu, X. AU - Walker, J. AU - Zhang, J. AU - Ding, S. AU - Schultz, P. G. PY - 2004 DA - 2004// TI - Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway JO - Chem Biol VL - 11 UR - https://doi.org/10.1016/j.chembiol.2004.06.010 DO - 10.1016/j.chembiol.2004.06.010 ID - Wu2004 ER - TY - JOUR AU - Sinha, S. AU - Chen, J. K. PY - 2006 DA - 2006// TI - Purmorphamine activates the Hedgehog pathway by targeting Smoothened JO - Nat Chem Biol VL - 2 UR - https://doi.org/10.1038/nchembio753 DO - 10.1038/nchembio753 ID - Sinha2006 ER - TY - JOUR AU - Fontaine, C. AU - Cousin, W. AU - Plaisant, M. AU - Dani, C. AU - Paraldi, P. PY - 2008 DA - 2008// TI - Hedgehog signaling alters adipocyte maturation of human mesenchymal stem cells JO - Stem Cells VL - 26 UR - https://doi.org/10.1634/stemcells.2007-0974 DO - 10.1634/stemcells.2007-0974 ID - Fontaine2008 ER - TY - JOUR AU - Taipale, J. AU - Chen, J. K. AU - Cooper, M. K. AU - Wang, B. AU - Mann, R. K. AU - Milenkovic, L. AU - Scott, M. P. AU - Beachy, P. A. PY - 2000 DA - 2000// TI - Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine JO - Nature VL - 406 UR - https://doi.org/10.1038/35023008 DO - 10.1038/35023008 ID - Taipale2000 ER - TY - JOUR AU - Kimura, H. AU - Ng, J. M. AU - Curran, T. PY - 2008 DA - 2008// TI - Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure JO - Cancer Cell VL - 13 UR - https://doi.org/10.1016/j.ccr.2008.01.027 DO - 10.1016/j.ccr.2008.01.027 ID - Kimura2008 ER - TY - JOUR AU - Zhou, J. X. AU - Jia, L. W. AU - Liu, W. M. AU - Miao, C. L. AU - Liu, S. AU - Cao, Y. J. AU - Duan, E. K. PY - 2006 DA - 2006// TI - Role of sonic hedgehog in maintaining a pool of proliferating stem cells in the human fetal epidermis JO - Hum Reprod VL - 21 UR - https://doi.org/10.1093/humrep/del086 DO - 10.1093/humrep/del086 ID - Zhou2006 ER - TY - JOUR AU - Pan, Y. AU - Wang, C. AU - Wang, B. PY - 2009 DA - 2009// TI - Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development JO - Dev Biol VL - 326 UR - https://doi.org/10.1016/j.ydbio.2008.11.009 DO - 10.1016/j.ydbio.2008.11.009 ID - Pan2009 ER - TY - JOUR AU - Wang, B. AU - Fallon, J. F. AU - Beachy, P. A. PY - 2000 DA - 2000// TI - Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb JO - Cell VL - 100 UR - https://doi.org/10.1016/S0092-8674(00)80678-9 DO - 10.1016/S0092-8674(00)80678-9 ID - Wang2000 ER - TY - JOUR AU - Tempé, D. AU - Casas, M. AU - Karaz, S. AU - Blanchet-Tournier, M. F. AU - Concordet, J. P. PY - 2006 DA - 2006// TI - Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP JO - Mol Cell Biol VL - 26 UR - https://doi.org/10.1128/MCB.02183-05 DO - 10.1128/MCB.02183-05 ID - Tempé2006 ER - TY - JOUR AU - Waschek, J. A. AU - Dicicco-Bloom, E. AU - Nicot, A. AU - Lelievre, V. PY - 2006 DA - 2006// TI - Hedgehog signaling: new targets for GPCRs coupled to cAMP and protein kinase A JO - Ann N Y Acad Sci VL - 1070 UR - https://doi.org/10.1196/annals.1317.089 DO - 10.1196/annals.1317.089 ID - Waschek2006 ER - TY - JOUR AU - Vaudry, D. AU - Falluel-Morel, A. AU - Bourgault, S. AU - Basille, M. AU - Burel, D. AU - Wurtz, O. AU - Fournier, A. AU - Chow, B. K. AU - Hashimoto, H. AU - Galas, L. AU - Vaudry, H. PY - 2009 DA - 2009// TI - Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after thediscovery JO - Pharmacol Rev VL - 61 UR - https://doi.org/10.1124/pr.109.001370 DO - 10.1124/pr.109.001370 ID - Vaudry2009 ER - TY - JOUR AU - Fila, T. AU - Trazzi, S. AU - Crochemore, C. AU - Bartesaghi, R. AU - Ciani, E. PY - 2009 DA - 2009// TI - Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation JO - J Biol Chem VL - 284 UR - https://doi.org/10.1074/jbc.M109.002329 DO - 10.1074/jbc.M109.002329 ID - Fila2009 ER - TY - STD TI - The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/10/676/prepub UR - http://www.biomedcentral.com/1471-2407/10/676/prepub ID - ref54 ER -