Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis

Hutter, Carolyn M; Slattery, Martha L; Duggan, David J; Muehling, Jill; Curtin, Karen; Hsu, Li; Beresford, Shirley AA; Rajkovic, Aleksandar; Sarto, Gloria E; Marshall, James R; Hammad, Nazik; Wallace, Robert; Makar, Karen W; Prentice, Ross L; Caan, Bette J; Potter, John D; Peters, Ulrike

doi:10.1186/1471-2407-10-670

BMC Cancer

Table 2 Associations between 8q24 SNPs and risk of colon cancer

From: Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis

			DALS						WHI						Combined
SNP	Location	Allele*	MAF	Genotype	Cases	Controls	OR (95% CI)	p	MAF	Genotype	Cases	Controls	OR (95% CI)	p	OR (95% CI)	p	I²
rs16902148	128476181	G→A	0.05	GG	1328	1615	1 (Ref)		0.05	GG	595	589	1 (Ref)
				GA	128	184	0.86 (0.68-1.09)			GA	46	57	0.81 (0.54-1.21)
				AA	2	3	0.84 (0.14-5.05)			AA	1	3	0.33 (0.03-3.18)
				log additive			0.86 (0.68-1.08)	0.203		log additive			0.75 (0.50-1.13)	0.168	0.83 (0.68-1.02)	0.073	0.0%
rs10505477	128476625	C→T	0.49	CC	307	424	1 (Ref)		0.50	CC	144	162	1 (Ref)
				CT	741	912	1.13 (0.95-1.35)			CT	323	328	1.10 (0.84-1.44)
				TT	405	461	1.23 (1.01-1.50)			TT	169	156	1.21 (0.88-1.65)
				log additive			1.11 (1.00-1.22)	0.045		log additive			1.08 (0.91-1.27)	0.384	1.10 (1.01-1.20)	0.026	0.0%
rs10808555	128478693	G→A	0.33	GG	604	797	1 (Ref)		0.33	GG	278	285	1 (Ref)
				GA	671	804	1.10 (0.95-1.28)			GA	279	293	0.97 (0.77-1.23)
				AA	182	198	1.21 (0.97-1.52)			AA	81	67	1.24 (0.86-1.79)
				log additive			1.10 (0.99-1.22)	0.067		log additive			1.08 (0.91-1.28)	0.395	1.10 (1.00-1.20)	0.047	0.0%
rs6983267	128482487	T→G	0.48	TT	284	400	1 (Ref)		0.49	TT	137	149	1 (Ref)
				TG	740	899	1.17 (0.97-1.40)			TG	303	326	1.00 (0.76-1.33)
				GG	424	486	1.23 (1.00-1.51)			GG	174	158	1.19 (0.87-1.63)
				log additive			1.11 (1.00-1.22)	0.048		log additive			1.09 (0.92-1.29)	0.336	1.10 (1.01-1.20)	0.023	0.0%
rs10956368	128492832	C→T	0.41	CC	472	634	1 (Ref)		0.39	CC	218	236	1 (Ref)
				CT	718	859	1.13 (0.96-1.32)			CT	295	316	1.00 (0.78-1.28)
				TT	260	301	1.16 (0.95-1.43)			TT	115	91	1.37 (0.98-1.91)
				log additive			1.09 (0.98-1.20)	0.100		log additive			1.12 (0.94-1.32)	0.201	1.10 (1.01-1.20)	0.035	0.0%
rs7005829	128504126	C→T	0.29	CC	703	925	1 (Ref)		0.28	CC	350	328	1 (Ref)
				CT	624	722	1.14 (0.99-1.32)			CT	237	270	0.82 (0.65-1.03)
				TT	129	152	1.12 (0.86-1.44)			TT	51	48	1.00 (0.66-1.53)
				log additive			1.09 (0.98-1.21)	0.113		log additive			0.94 (0.78-1.13)	0.523	1.03 (0.90-1.19)	0.647	53.4%
rs9297756	128509349	C→T	0.15	CC	980	1290	1 (Ref)		0.16	CC	462	450	1 (Ref)
				CT	428	458	1.23 (1.05-1.44)			CT	158	181	0.84 (0.65-1.08)
				TT	46	42	1.42 (0.92-2.17)			TT	15	11	1.36 (0.62-3.01)
				log additive			1.22 (1.07-1.39)	0.004		log additive			0.93 (0.74-1.18)	0.570	1.08 (0.83-1.41)	0.547	78.4%
rs12334695	128523110	T→C	0.38	TT	522	684	1 (Ref)		0.38	TT	252	245	1 (Ref)
				TC	678	833	1.08 (0.93-1.26)			TC	286	304	0.90 (0.71-1.15)
				CC	235	268	1.16 (0.94-1.43)			CC	95	89	1.04 (0.74-1.46)
				log additive			1.08 (0.97-1.19)	0.148		log additive			1.01 (0.85-1.19)	0.937	1.06 (0.97-1.16)	0.186	0.0%
rs10109622	128527333	C→T	0.23	CC	896	1077	1 (Ref)		0.23	CC	393	388	1 (Ref)
				CT	478	622	0.92 (0.79-1.07)			CT	203	220	0.91 (0.72-1.15)
				TT	83	99	1.02 (0.76-1.39)			TT	39	38	1.01 (0.63-1.62)
				log additive			0.96 (0.86-1.08)	0.537		log additive			0.99 (0.82-1.20)	0.954	0.97 (0.88-1.07)	0.512	0.0%
rs10094059	128530789	G→C	0.24	GG	847	1030	1 (Ref)		0.25	GG	346	378	1 (Ref)
				GC	523	677	0.94 (0.81-1.08)			GC	258	221	1.28 (1.01-1.61)
				CC	87	93	1.13 (0.83-1.53)			CC	41	55	0.82 (0.53-1.26)
				log additive			0.99 (0.88-1.11)	0.908		log additive			1.01 (0.84-1.22)	0.888	1.00 (0.90-1.10)	0.929	0.0%
rs7841264	128535996	C→T	0.18	CC	1009	1190	1 (Ref)		0.17	CC	449	444	1 (Ref)
				CT	395	546	0.85 (0.73-0.99)			CT	166	174	0.95 (0.74-1.22)
				TT	50	59	1.01 (0.68-1.48)			TT	15	22	0.68 (0.34-1.33)
				log additive			0.90 (0.79-1.03)	0.118	0.17	log additive			0.93 (0.75-1.16)	0.526	0.91 (0.81-1.02)	0.095	0.0%

* Reference allele is listed first. Reference allele is the common allele for all SNPs but rs10505477 and rs6983267. Those two SNPs have minor allele as reference for better comparison with previously published studies. DALS=Diet, activity and lifestyle study; WHI= Women's Health Intitiative; MAF=minor allele frequency; p=p-value from test of trend with genotype coded 0/1/2. I-squared measures between study heterogeneity. Associations significant at alpha level=0.05 are shown in bold.

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ISSN: 1471-2407

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