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Table 2 Associations between 8q24 SNPs and risk of colon cancer

From: Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis

    DALS WHI Combined  
SNP Location Allele* MAF Genotype Cases Controls OR (95% CI) p MAF Genotype Cases Controls OR (95% CI) p OR (95% CI) p I2
rs16902148 128476181 G→A 0.05 GG 1328 1615 1 (Ref)   0.05 GG 595 589 1 (Ref)     
     GA 128 184 0.86 (0.68-1.09)    GA 46 57 0.81 (0.54-1.21)     
     AA 2 3 0.84 (0.14-5.05)    AA 1 3 0.33 (0.03-3.18)     
     log additive    0.86 (0.68-1.08) 0.203   log additive    0.75 (0.50-1.13) 0.168 0.83 (0.68-1.02) 0.073 0.0%
rs10505477 128476625 C→T 0.49 CC 307 424 1 (Ref)   0.50 CC 144 162 1 (Ref)     
     CT 741 912 1.13 (0.95-1.35)    CT 323 328 1.10 (0.84-1.44)     
     TT 405 461 1.23 (1.01-1.50)    TT 169 156 1.21 (0.88-1.65)     
     log additive    1.11 (1.00-1.22) 0.045   log additive    1.08 (0.91-1.27) 0.384 1.10 (1.01-1.20) 0.026 0.0%
rs10808555 128478693 G→A 0.33 GG 604 797 1 (Ref)   0.33 GG 278 285 1 (Ref)     
     GA 671 804 1.10 (0.95-1.28)    GA 279 293 0.97 (0.77-1.23)     
     AA 182 198 1.21 (0.97-1.52)    AA 81 67 1.24 (0.86-1.79)     
     log additive    1.10 (0.99-1.22) 0.067   log additive    1.08 (0.91-1.28) 0.395 1.10 (1.00-1.20) 0.047 0.0%
rs6983267 128482487 T→G 0.48 TT 284 400 1 (Ref)   0.49 TT 137 149 1 (Ref)     
     TG 740 899 1.17 (0.97-1.40)    TG 303 326 1.00 (0.76-1.33)     
     GG 424 486 1.23 (1.00-1.51)    GG 174 158 1.19 (0.87-1.63)     
     log additive    1.11 (1.00-1.22) 0.048   log additive    1.09 (0.92-1.29) 0.336 1.10 (1.01-1.20) 0.023 0.0%
rs10956368 128492832 C→T 0.41 CC 472 634 1 (Ref)   0.39 CC 218 236 1 (Ref)     
     CT 718 859 1.13 (0.96-1.32)    CT 295 316 1.00 (0.78-1.28)     
     TT 260 301 1.16 (0.95-1.43)    TT 115 91 1.37 (0.98-1.91)     
     log additive    1.09 (0.98-1.20) 0.100   log additive    1.12 (0.94-1.32) 0.201 1.10 (1.01-1.20) 0.035 0.0%
rs7005829 128504126 C→T 0.29 CC 703 925 1 (Ref)   0.28 CC 350 328 1 (Ref)     
     CT 624 722 1.14 (0.99-1.32)    CT 237 270 0.82 (0.65-1.03)     
     TT 129 152 1.12 (0.86-1.44)    TT 51 48 1.00 (0.66-1.53)     
     log additive    1.09 (0.98-1.21) 0.113   log additive    0.94 (0.78-1.13) 0.523 1.03 (0.90-1.19) 0.647 53.4%
rs9297756 128509349 C→T 0.15 CC 980 1290 1 (Ref)   0.16 CC 462 450 1 (Ref)     
     CT 428 458 1.23 (1.05-1.44)    CT 158 181 0.84 (0.65-1.08)     
     TT 46 42 1.42 (0.92-2.17)    TT 15 11 1.36 (0.62-3.01)     
     log additive    1.22 (1.07-1.39) 0.004   log additive    0.93 (0.74-1.18) 0.570 1.08 (0.83-1.41) 0.547 78.4%
rs12334695 128523110 T→C 0.38 TT 522 684 1 (Ref)   0.38 TT 252 245 1 (Ref)     
     TC 678 833 1.08 (0.93-1.26)    TC 286 304 0.90 (0.71-1.15)     
     CC 235 268 1.16 (0.94-1.43)    CC 95 89 1.04 (0.74-1.46)     
     log additive    1.08 (0.97-1.19) 0.148   log additive    1.01 (0.85-1.19) 0.937 1.06 (0.97-1.16) 0.186 0.0%
rs10109622 128527333 C→T 0.23 CC 896 1077 1 (Ref)   0.23 CC 393 388 1 (Ref)     
     CT 478 622 0.92 (0.79-1.07)    CT 203 220 0.91 (0.72-1.15)     
     TT 83 99 1.02 (0.76-1.39)    TT 39 38 1.01 (0.63-1.62)     
     log additive    0.96 (0.86-1.08) 0.537   log additive    0.99 (0.82-1.20) 0.954 0.97 (0.88-1.07) 0.512 0.0%
rs10094059 128530789 G→C 0.24 GG 847 1030 1 (Ref)   0.25 GG 346 378 1 (Ref)     
     GC 523 677 0.94 (0.81-1.08)    GC 258 221 1.28 (1.01-1.61)     
     CC 87 93 1.13 (0.83-1.53)    CC 41 55 0.82 (0.53-1.26)     
     log additive    0.99 (0.88-1.11) 0.908   log additive    1.01 (0.84-1.22) 0.888 1.00 (0.90-1.10) 0.929 0.0%
rs7841264 128535996 C→T 0.18 CC 1009 1190 1 (Ref)   0.17 CC 449 444 1 (Ref)     
     CT 395 546 0.85 (0.73-0.99)    CT 166 174 0.95 (0.74-1.22)     
     TT 50 59 1.01 (0.68-1.48)    TT 15 22 0.68 (0.34-1.33)     
     log additive    0.90 (0.79-1.03) 0.118 0.17 log additive    0.93 (0.75-1.16) 0.526 0.91 (0.81-1.02) 0.095 0.0%
  1. * Reference allele is listed first. Reference allele is the common allele for all SNPs but rs10505477 and rs6983267. Those two SNPs have minor allele as reference for better comparison with previously published studies. DALS=Diet, activity and lifestyle study; WHI= Women's Health Intitiative; MAF=minor allele frequency; p=p-value from test of trend with genotype coded 0/1/2. I-squared measures between study heterogeneity. Associations significant at alpha level=0.05 are shown in bold.