Figure 5

Effect of ATF3 down-regulation on hepatic tumor growth in vivo. A hepatic tumor cell implantation model was used to determine the effects of ATF3 down-regulation on hepatic tumor growth and metastasis of HCT116 cells. A) Animals in the ATF3-shRNA group had a markedly greater hepatic tumor burden, as determined by measuring the weight of excised tumors (*P < 0.05). B) The occurrence of hepatic nodules in liver lobes other than the injected lobe was significantly greater in animals of the ATF3-shRNA group (*P < 0.05). C) Representative images of hepatic tumor burden are shown. Bars: mean ± SEM