Skip to main content
Figure 2 | BMC Cancer

Figure 2

From: Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer

Figure 2

Immunohistochemical staining of VEGF-A, PDGF-B, PDGFR-β and CD34 with hematoxylin and eosin staining (HE) in representative tissue sections obtained from human gastric carcinoma. According to the presence/absence in overexpression of VEGF and PDGF, as measured by a summation score of staining intensity and proportion of positive staining cells for VEGF-A and PDGF-B, cases were classified to 4 types: Type1, VEGF-A+/PDGF-B+; Type2, VEGF-A+PDGF-B-; Type3, VEGF-A-/PDGF-B+; Type4, VEGF-A-/PDGF-B-. Immunoreactivity for VEGF-A is detected predominantly in the cytoplasm of the carcinoma cells (arrow), whereas PDGF-B reactivity is strong in the nuclei and weak in the cytoplasm (arrow head). Staining for PDGFR-β was seen in many pericytes (outline arrow) of PDGF-B overexpressing carcinomas, implying that PDGF produced by cancer cells caused increased pericyte coverage around vessels.

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us