Skip to main content

Table 2 Overlapping gains and losses that differentiate BLBCs and BRCA1-mutated tumors from luminal breast tumors

From: BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

a Chr - region Start (Mb) End (Mb) peaks (Mb) BRCA1-related peaks (Mb) BLBC
Gains 1p 58.05 65.50 62.00 61.20
  2p-1 23.35 25.95 26.45 27.45
  2p-2 56.80 65.20 60.85 63.95
  3q-1 151.00 161.10 150.85 154.85
  3q-2 175.80 186.40 178.55 179.80
  6p-1 4.30 29.75 10.90, 19.20 14.05
  6p-2 37.05 58.65 42.60, 53.85 36.65
  6q-1 90.35 90.75 86.50 91.00
  6q-2 105.20 112.30 107.15 107.75
  6q-3 115.00 120.40 no peak in region  
  6q-4 123.55 138.75 125.55 135.60
  7q-1 132.80 139.40 134.40 130.25
  7q-2 155.15 157.65 156.95 157.65
  8q 127.40 132.95 120.95 121.95, 135.3
  10p-1 1.30 12.45 5.10 6.45
  10p-2 25.65 30.70 24.90 29.20
  12p 0.25 11.60 0.25, 16.10 0.25
  13q 101.25 107.00 99.55 110.35
  19q 36.50 41.75 39.15 41.10
Losses 3p 53.00 53.25 53.85 62.55
  4p 15.65 27.05 18.55 11.00, 26.65
  5q-1 50.05 146.95 57.70, 70.75, 89.75,102.30, 116.25, 133.80 70.05, 89.85, 108.60,118.55, 136.30
  5q-2 161.40 171.20 161.05, 178.30 157.30
  10q-1 80.65 95.50 83.30, 90.15 91.05
  10q-2 105.55 111.35 109.70 108.60
  12q-1 47.70 48.35 no peak in region 42.15
  12q-2 54.30 59.25 55.25 58.40
  14q-1 38.30 44.75 40.65 36.35
  14q-2 48.35 92.95 57.35, 79.90, 98.00 55.20, 66.15, 81.0, 95.05
  15q 35.10 49.65 44.40 33.70, 42.85
b Chr - region Start (Mb) End (Mb) peaks (Mb)  
Gains 1q 176.70 215.40 177.35, 202.75  
  8p 35.95 38.90 41.5  
  16p 4.30 27.75 15.8  
Losses 6q-1 79.05 87.25 82.35  
  6q-2 142.75 149.25 no peak in region  
  6q-3 156.90 157.85 160.05  
  11q 104.45 125.35 112.30, 126.60  
  13q 91.70 95.50 99.1  
  16q 45.15 88.50 52.30, 79.40  
  1. Table 2: a. Overlapping differential CNAs of BLBCs and BRCA1-mutated breast tumors vs luminal breast tumors. b. Overlapping differential CNAs of luminal breast tumors vs BRCA1-mutated breast tumors and BLBCs.
  2. Differential gains and losses determined by comparative-KC-SMART (Figure 1b-c). a) Overlapping regions that differentiate BRCA1-mutated tumors and BLBCs from luminal tumors. b) overlapping regions that differentiate luminal-J and luminal-H tumors from BLBC/BRCA1-mutated tumors. KSE peak locations are listed for all tumor groups; peaks in italics fall just outside the region of overlap.