Median number of aberrations. a: Median amount of aberrations of BRCA1-mutated tumors and BLBCs. Normalized aCGH profiles from individual tumors were smoothed using KC-SMART (kernel width: 20 Mb) for a range of thresholds (KSE cutoff, x-axis). Gains exceeding a positive threshold and losses exceeding the same negative threshold were counted and the median was calculated over each tumor group. Gray background indicates thresholds for which the average number of CNAs in the BLBC group is significantly different compared with the luminal tumors, calculated with a two sided t-test (P < 0.01). Median amount of aberrations of (b) BRCA1-mutated tumors (blue dots) and luminal tumors (black dots); (c) BLBCs (red dots) and luminal breast tumors (black dots); (d) luminal-H (dark gray dots) and luminal-J tumors (light gray dots).