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Figure 2 | BMC Cancer

Figure 2

From: BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

Figure 2

Comparative-KC-SMART analysis of aCGH data from BRCA1-mutated tumors and BLBCs. For each tumor group, comparative-KC-SMART was applied to normalized aCGH data, which was scaled to have a mean of zero and a standard deviation of one. The KSE curves for each tumor group are shown for gains and losses separately. a: BRCA1-mutated breast tumors (blue) vs. BLBCs (gray). CNAs that occur more often in the BRCA1-mutated tumors vs. the BLBCs are shown as red horizontal bars on above or below the KSEgains and KSElosses respectively, and they are plotted as red overlays on the blue KSE curves. CNAs that occur more often the BLBCs vs. the BRCA1-mutated tumors are shown as green horizontal bars above or below the KSEgains and KSElosses respectively, and as green overlays on the gray KSE curves. b: BRCA1-mutated tumors (blue) vs. luminal tumors (gray) c: BLBCs (blue) vs. luminal (gray) tumors. d: Luminal-J tumors (blue) vs. luminal-H tumors (gray).

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