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Figure 1 | BMC Cancer

Figure 1

From: BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

Figure 1

Analysis of TP53 mutations in BRCA1-mutated tumors and BLBCs. TP53 exons 2-9 were sequenced for 21/27 of the BRCA1-mutated tumors and for 13/21 of the luminal-J tumors. TP53 exons 2-11 were sequenced for all 21 BLBCs and 31 luminal-H tumors (see Table 1 for TP53 mutations see Additional File 1 for TP53 mutation frequencies). a. Amount of tumors with at least one TP53 mutation. b. Amount of tumors with at least one complex, predicted truncating TP53 mutation (frameshift, splice and nonsense mutations and in-frame insertions/deletions). c. Amount of tumors with at least one deleterious missense mutation. d. the amount of tumors with at least one hotspot mutation as defined by Walker et al. Three BRCA1-mutated tumors have a complex/truncating TP53 mutation and also a deleterious missense mutation. * Significant difference between groups (p < 0.01, determined with a Fisher's Exact Test), ns: no significant difference between groups.

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