Table 2 Cox regression analyses by molecular subgroup, by immunohistochemistry
All (n = 392) | Breast Conserving Surgery (n = 298) | |||
|---|---|---|---|---|
Univariate HR (95% CI) | Adjusted* HR (95% CI) | Univariate HR (95% CI) | Adjusted* HR (95% CI) | |
Event: local recurrence (n = 76) | ||||
Gene-expression classification | ||||
Non basal-like (n = 360) | 1 (Reference) | 1 | 1 | 1 |
Basal-like (n = 32) | 1.7 (0.8-3.8) | 1.9 (0.8-4.2) | 1.6 (0.7-3.6) | 1.8 (0.7-4.2) |
Triple-negative classification | ||||
Non triple-negative (n = 377) | 1 (Reference) | 1 | 1 | 1 |
Triple-negative (n = 32) | 1.1 (0.4-2.7) | 1.1 (0.4-2.9) | 1.0 (0.4-2.7) | 1.0 (0.3-2.9) |
Tumor grade | ||||
I (n = 30) | 1 (Reference) | 1 | 1 | 1 |
II (n = 182) | 1.2 (0.4-3.4) | 1.4 (0.5-4.0) | 1.3 (0.5-3.9) | 1.4 (0.5-3.9) |
III (n = 176) | 1.0 (0.3-2.9) | 1.3 (0.5-3.9) | 1.4 (0.5-4.0) | 1.4 (0.5-4.2) |
Postoperation radiotherapy | ||||
No (n = 252) | 1 (Reference) | 1 | 1 | 1 |
Yes (n = 140) | 0.9 (0.5-1.5) | 0.7 (0.4-1.3) | 0.8 (0.4-1.4) | 0.7 (0.4-1.4) |
Event: invasive- and general recurrence (n = 47) | ||||
Gene-expression classification | ||||
Non basal-like (n = 360) | 1 (Reference) | 1 | 1 | 1 |
Basal-like (n = 32) | 2.0 (0.8-5.0) | 1.9 (0.7-5.1) | 2.2 (0.8-5.6) | 2.3 (0.8-6.1) |
Triple-negative classification | ||||
Non triple-negative (n = 377) | 1 (Reference) | 1 | 1 | 1 |
Triple-negative (n = 32) | 1.4 (0.5-4.0) | 1.6 (0.6-4.8) | 1.7 (0.6-4.9) | 2.1 (0.7-6.3) |
Tumor grade | ||||
I (n = 30) | 1 (Reference) | 1 | 1 | 1 |
II (n = 182) | 1.0 (0.3-3.3) | 1.1 (0.3-3.8) | 1.1 (0.3-3.8) | 1.1 (0.3-3.8) |
III (n = 176) | 0.7 (0.2-2.4) | 1.1 (0.3-3.9) | 0.9 (0.2-3.1) | 1.0 (0.3-3.9) |
Postoperation radiotherapy | ||||
No (n = 252) | 1 (Reference) | 1 | 1 | 1 |
Yes (n = 140) | 0.8 (0.4-1.6) | 0.7 (0.3-1.5) | 0.7 (0.3-1.4) | 0.7 (0.3-1.6) |