Table 3 Multivariate analysis with respect to overall survival (n = 135).

P-Smad2 expression

0.627

0.347-1.133

0.122

   Low vs. high

Morphologic feature

2.325

1.221-4.388

0.010

   Type 1, 2, and 3 vs. type 4

Differentiation

2.807

1.251-6.298

0.012

   Intestinal-type vs. Diffuse-type

Lymph node metastasis (Japanese classification)

1.387

0.689-2.794

0.360

   N0 and N1 vs. N2 and N3

Peritoneal dissemination

1.097

0.549-2.193

0.793

   Negative vs. positive

Lymphatic invasion

1.394

0.805-2.413

0.235

   Ly0 and ly1 vs. ly2 and ly3

Clinical Stage

4.382

1.924-9.978

< 0.001

   I, II, and III vs. IV