Phosphorylated Smad2 in Advanced Stage Gastric Carcinoma

BMC Cancer

Table 1 Relationships between p-Smad2 and clinicopathological features in 135 gastric cancer cases.

Parameter		P-Smad2		p-Value
		High (n = 63)	Low (n = 72)
Gender
	Male	39 (41.9%)	54 (58.1%)	N.S.
	Female	24 (57.1%)	18 (42.9%)
Morphologic feature⁺
	Type 1	6 (37.5%)	10 (62.5%)	0.025
	Type 2	14 (35.0%)	26 (65.0%)
	Type 3	17 (45.9%)	20 (54.1%)
	Type 4	26 (61.9%)	16 (38.1%)
T stage
	2	7 (25.9%)	20 (74.1%)	0.031
	3	52 (50.0%)	52 (50.0%)
	4	4 (100.0%)	0 (0.00%)
Differentiation
	Intestinal-type	15 (31.2%)	33 (68.8%)	0.011
	Diffuse-type	48 (55.2%)	39 (44.8%)
Lymph node metastasis⁺ (Japanese classification)	N0 and N1	34 (40.5%)	50 (59.5%)	0.047
	N2 and N3	29 (56.9%)	22 (43.1%)
Lymph node metastasis⁺⁺ (UICC classification)	N0 and N1	31 (36.9%)	53 (63.1%)	0.004
	N2 and N3	32 (62.7%)	19 (37.3%)
Hepatic metastasis
	Negative	62 (47.0%)	70 (53.0%)	N.S.
	Positive	1 (33.3%)	2 (66.7%)
Peritoneal metastasis
	Negative	48 (42.1%)	66 (57.9%)	0.017
	Positive	15 (71.4%)	6 (28.6%)
Peritoneal cytology⁺⁺⁺
	Negative	36 (40.4%)	53 (59.6%)	0.026
	Positive	22 (64.7%)	12 (35.3%)
Lymphatic invasion
	Ly0 and ly1	26 (40.6%)	38 (59.4%)	N.S.
	Ly2 and ly3	37 (52.1%)	34 (47.9%)
Venous invasion
	Negative	50 (45.5%)	60 (54.5%)	N.S.
	Positive	13 (52.0%)	12 (48.0%)
Clinical stage
	I	2 (22.2%)	7 (77.8%)	0.022
	II	15 (39.5%)	23 (60.5%)
	III	18 (40.0%)	27 (60.0%)
	IV	28 (68.7%)	15 (31.3%)

^+, Classification according to the General Rules for Gastric Cancer Study of the Japanese Research Society for Gastric Cancer [13]. Type 1 is defined as a polypoid tumor; type 2 as polypoid tumor with ulceration and with sharply demarcated margins; type 3 as ulcerated carcinoma with cancer infiltration into the surrounding wall; type 4 as diffusely infiltrating flat carcinoma in which ulceration is usually not a marked feature.
^++, Nodal stage was assessed by the Union Internationale Contre le Cancer (UICC) tumor node metastasis (TNM) classification [16] and by classification according to the general rules for gastric cancer study of the Japanese Research Society for Gastric Cancer. In the TNM classification, nodal stage was classified according to the number of involved regional LNs as follows: pN0, no LN spread; pN1, 1 to 6 diseased LNs; pN2, 7 to 15; and pN3, more than 15. In the Japanese classification, nodal stage was classified according to the extent of positive LN into n0, n1, n2, and n3 and is considered to reflect the anatomic pathway of lymphatic spread. n1 is defined as proximate regional LN disease, and n2 or n3 are defined as distant.
^+++, In 12 cases, peritoneal cytology was not performed (Total 123 cases).

ISSN: 1471-2407