Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study

Table 4 Relation of viral load and ratio of E2 to E6/7 of HP-HPV infection and clinical characteristics of ESCC and CSCC patients

Characteristics	No. of subjects	HPV viral load (mean ± SE)	t/F/Zstatistic	P*	HPV E2:E6/7 ratio (mean ± SE)	t/F/Z/statistic	P*
ESCC patients
Age (years)
54.42 ± 7.86	38	2.55 ± 3.19	-0.152	0.364^#	0.201 ± 0.325	0.049	0.771^#
Lymph node metastasis
Yes	20	2.98 ± 3.81	0.879	0.385	0.22 ± 0.30	-0.731	0.478
No	18	2.07 ± 2.34			0.18 ± 0.34
Cancer grade
I	13	1.65 ± 3.42			0.39 ± 0.43
II	20	2.96 ± 3.32	0.799	0.458	0.12 ± 0.23	8.361	0.015
III	5	3.24 ± 1.60			0.05 ± 0.11
CSCC patients
Age (years)
43.42 ± 8.44	35	361.29 ± 441.74	-0.108	0.537^#	0.09 ± 0.14	-0.184	0.289^#
Lymph node metastasis
Yes	10	330.03 ± 316.40	-0.110	0.913	0.11 ± 0.12	-1.278	0.201
No	25	373.80 ± 448.21			0.08 ± 0.16
Cancer grade
I	14	188.68 ± 374.64			0.17 ± 0.19
II	12	340.28 ± 262.40	9.542	0.008	0.06 ± 0.09	6.363	0.042
III	9	660.97 ± 592.94			0.007 ± 0.001

*P values for the differences of HPV viral load and ratio of E2 to E6/7 among different groups was calculated with the independent-samples t test or Mann-Whitney-U test, one-way ANOVA or Kruskal-Wallis assay as appropriate.
^# P values for the correlation between the age of patients and HPV viral load, as well as HPV ratios of E2 to E6/7 were calculated by Spearman correlation.
ESCC, esophageal squamous cell carcinoma; CSCC, cervical squamous cell carcinoma.

ISSN: 1471-2407