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Table 4 Relation of viral load and ratio of E2 to E6/7 of HP-HPV infection and clinical characteristics of ESCC and CSCC patients

From: Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study

Characteristics No. of subjects HPV viral load (mean ± SE) t/F/Zstatistic P* HPV E2:E6/7 ratio (mean ± SE) t/F/Z/statistic P*
ESCC patients        
Age (years)        
   54.42 ± 7.86 38 2.55 ± 3.19 -0.152 0.364# 0.201 ± 0.325 0.049 0.771#
Lymph node metastasis        
   Yes 20 2.98 ± 3.81 0.879 0.385 0.22 ± 0.30 -0.731 0.478
   No 18 2.07 ± 2.34    0.18 ± 0.34   
Cancer grade        
   I 13 1.65 ± 3.42    0.39 ± 0.43   
   II 20 2.96 ± 3.32 0.799 0.458 0.12 ± 0.23 8.361 0.015
   III 5 3.24 ± 1.60    0.05 ± 0.11   
CSCC patients        
Age (years)        
   43.42 ± 8.44 35 361.29 ± 441.74 -0.108 0.537# 0.09 ± 0.14 -0.184 0.289#
Lymph node metastasis        
   Yes 10 330.03 ± 316.40 -0.110 0.913 0.11 ± 0.12 -1.278 0.201
   No 25 373.80 ± 448.21    0.08 ± 0.16   
Cancer grade        
   I 14 188.68 ± 374.64    0.17 ± 0.19   
   II 12 340.28 ± 262.40 9.542 0.008 0.06 ± 0.09 6.363 0.042
   III 9 660.97 ± 592.94    0.007 ± 0.001   
  1. *P values for the differences of HPV viral load and ratio of E2 to E6/7 among different groups was calculated with the independent-samples t test or Mann-Whitney-U test, one-way ANOVA or Kruskal-Wallis assay as appropriate.
  2. # P values for the correlation between the age of patients and HPV viral load, as well as HPV ratios of E2 to E6/7 were calculated by Spearman correlation.
  3. ESCC, esophageal squamous cell carcinoma; CSCC, cervical squamous cell carcinoma.