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Table 3 HPV-16, -18 and -58 prevalence, viral load and physical status in patients with ESCC and CSCC, and in their corresponding controls

From: Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study

Origin Total No. (%) Viral load (copies/cell) Physical status (E2:E6/7 ratio)
    Min-max Mean ± SD Mean ± SD Episomal Mixed Integration
HPV16       >0.86 0. 10-0.86 0.001-0.10 <0.001
ESCC 70 21(30.00) 0.02-9.28 2.19 ± 2.60 0.25 ± 0.37 2 5 8 6
NE 60 13(21.67) 0.04-2.08 0.55 ± 0.16 0.51 ± 0.36 3 7 2 1
CSCC 39 19(48.72) 32.03-1546.38 468.39 ± 473.36 0.03 ± 0.08 0 5 5 9
NC 54 8(14.81) 0.12-122.92 26.21 ± 34.26 0.59 ± 0.44 4 3 1 0
HPV18       >0.82 0. 10-0.82 0.00-0.10 <0.001
ESCC 70 8(11.43) 0.00-11.29 2.03 ± 3.88 0.17 ± 0.14 0 1 6 1
NE 60 3(2.00) 0.03-2.25 0.73 ± 1.26 0.37 ± 0.14 0 2 0 1
CSCC 39 7(17.95) 5.14-295.38 174.77 ± 121.20 0.06 ± 0.10 0 2 3 2
NC 54 2(3.70) 1.22-130.51 65.87 ± 91.42 0.60 ± 0.34 1 1 0 0
HPV58       >0.78 0. 10-0.78 0.001-0.10 <0.001
ESCC 70 9(21.43) 0.03-12.56 3.86 ± 3.82 0.17 ± 0.32 1 1 3 4
NE 60 4(6.67) 0.17-2.65 1.68 ± 1.09 0.35 ± 0.31 0 3 1 0
CSCC 39 9(23.08) 4.11-1521.70 280.27 ± 499.13 0.12 ± 0.18 0 3 0 6
NC 54 2(3.70) 0.99-106.59 53.79 ± 74.67 0.64 ± 0.26 1 1 0 0
3 HR-HPVs          
ESCC 70 35(50.00) 0.00-12.56 2.55 ± 3.19 a 0.20 ± 0.32 3 6 16 10d
NE 60 20(33.33) 0.04-2.08 0.55 ± 0.57 0.53 ± 0.33 3 12 3 2
CSCC 39 31(79.48) 4.11-1546.38 361.29 ± 441.75bc 0.09 ± 0.14 0 9 6 16e f
NC 54 10(18.52) 0.12-853.43 30.87 ± 57.39 0.55 ± 0.40 6 3 1 0
  1. a Z = -2.594, P = 0.029, compared with NE group; b Z = -3.115, P = 0.002 and c Z = -4.827, P < 0.001, compared with ESCC patients and NC group, respectively, and calculated with the Mann-Whitney-U test.
  2. d χ 2 = 12.703, P = 0.004; e χ 2 = 22.544, P < 0.001; f χ 2 = 8.850, P = 0.022 compared with NE group. NC group and ESCC patients, respectively, and calculated with the Chi-square test or Fisher exact test as appropriate.
  3. ESCC, esophageal squamous cell carcinoma; CSCC, cervical squamous cell carcinoma; NE, normal esophagus; NC, normal cervix.