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Table 4 Sensitivity and specificity of urine markers when including follow-up data for detection of bladder cancer

From: Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts

  Sensitivity Specificity AUC OR 95% CI PPV NPV P-value
hTERT 62 84.1 0.73 8.63 3.47-21.4 87.5 55.2 < 0.001
MCM5 61 73.3 0.67 4.3 1.66-11.1 81.8 48.9 0.002
SENP1 53.2 84.1 0.69 6 2.43-14.7 85.7 50 < 0.001
PPP1CA 64.6 65.9 0.65 3.52 1.63-7.6 77.3 50.9 0.001
Cyt2-3* 42.7 100 0.71    100 50 < 0.001
MCM5+Cyt2-3* 73.2 75.9 0.75 8.59 3.09-23.8 85.4 59.5 < 0.001
hTERT+Cyt 2-3* 70.7 86 0.78 14.9 5.59-39.2 89.8 62.7 < 0.001
hTERT+SENP1** 68.4 75 0.72 6.48 2.85-14.7 83.1 56.8 < 0.001
hTERT+MCM5 71.2 66.7 0.69 4.94 1.94-12.6 80.8 54.1 0.001
hTERT+MCM5+Cyt2-3* 73.2 75.9 0.75 8.59 3.09- 23.8 85.4 59.5 < 0.001
  1. * Positive cytology defined by atypical cells grade 2 or 3 in the urine.
  2. **Considered positive if either SENP1 or hTERT or both are positive.