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Table 4 Sensitivity and specificity of urine markers when including follow-up data for detection of bladder cancer

From: Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts

 

Sensitivity

Specificity

AUC

OR

95% CI

PPV

NPV

P-value

hTERT

62

84.1

0.73

8.63

3.47-21.4

87.5

55.2

< 0.001

MCM5

61

73.3

0.67

4.3

1.66-11.1

81.8

48.9

0.002

SENP1

53.2

84.1

0.69

6

2.43-14.7

85.7

50

< 0.001

PPP1CA

64.6

65.9

0.65

3.52

1.63-7.6

77.3

50.9

0.001

Cyt2-3*

42.7

100

0.71

  

100

50

< 0.001

MCM5+Cyt2-3*

73.2

75.9

0.75

8.59

3.09-23.8

85.4

59.5

< 0.001

hTERT+Cyt 2-3*

70.7

86

0.78

14.9

5.59-39.2

89.8

62.7

< 0.001

hTERT+SENP1**

68.4

75

0.72

6.48

2.85-14.7

83.1

56.8

< 0.001

hTERT+MCM5

71.2

66.7

0.69

4.94

1.94-12.6

80.8

54.1

0.001

hTERT+MCM5+Cyt2-3*

73.2

75.9

0.75

8.59

3.09- 23.8

85.4

59.5

< 0.001

  1. * Positive cytology defined by atypical cells grade 2 or 3 in the urine.
  2. **Considered positive if either SENP1 or hTERT or both are positive.