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Table 3 Sensitivity and specificity of the urine markers when using cystoscopy as gold standard for detection of bladder cancer

From: Prediction and diagnosis of bladder cancer recurrence based on urinary content of hTERT, SENP1, PPP1CA, and MCM5 transcripts

  Sens. Spec. AUC OR 95%CI PPV NPV P(chi2)
hTERT 62.5 72.9 0.68 4.48 2.09-9.58 71.4 64.2 < 0.001
PPP1CA 68.8 62.7 0.66 3.7 1.76-7.77 66.7 64.9 < 0.001
SENP1 56.3 78 0.67 4.55 2.08-9.94 73.5 62.2 < 0.001
MCM5 62.5 65.9 0.64 3.21 1.36-7.62 68.2 60 0.008
Cytology ALL* 41.7 87.9 0.65 5.2 2.06-13.1 78.1 59.3 < 0.001
Cytology Gr.2-3(Cyt2-3) 48.3 79.3 0.64 3.59 1.6-8 70.7 59.7 0.002
Cyt2-3+hTERT** 73.3 74.1 0.74 7.88 3.49-17.8 74.6 72.9 < 0.001
Cyt2-3+MCM5** 77.8 67.5 0.73 7.27 2.8-18.9 72.9 73 < 0.001
Cyt2-3+ SENP1** 65 74.1 0.70 5.32 2.42-11.7 72.2 67.2 < 0.001
Cyt2-3+PPP1CA** 75 60.3 0.68 4.57 2.09-9.96 66.2 70 < 0.001
Cyt2-3+MCM5+hTERT*** 77.8 67.5 0.73 7.27 2.8-18.9 72.9 73 < 0.001
  1. * All atypical cells in the urine recorded as positive.
  2. ** One or both positive.
  3. *** If only hTERT was positive then the combined score was classified as negative.