TY - JOUR AU - Djokovic, Dusan AU - Trindade, Alexandre AU - Gigante, Joana AU - Badenes, Marina AU - Silva, Lilliana AU - Liu, Ren AU - Li, Xiuqing AU - Gong, Ming AU - Krasnoperov, Valery AU - Gill, Parkash S. AU - Duarte, Antonio PY - 2010 DA - 2010/11/23 TI - Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis JO - BMC Cancer SP - 641 VL - 10 IS - 1 AB - Dll4/Notch and Ephrin-B2/EphB4 pathways play critical roles in tumor vessel development and maturation. This study evaluates the efficacy of the inhibition of both signaling pathways, alone and in combination, in reducing the growth of an autochthonous mouse tumor and assesses potential adverse effects. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-10-641 DO - 10.1186/1471-2407-10-641 ID - Djokovic2010 ER -