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Table 1 Expression and regulation of PFKFB2 in different lymphoid systems1

From: Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells

  Expression
(mE-value)
Regulation
(mM-value)
Regulation
(mM-value)
samples 15A 15B 15A 6/8 h 15A 24 h 15B 6/8 h 15B 24 h
T-ALL (6) 6.3 ± 1.5 4.0 ± 1.9 1.7 ± 1.5 2.4 ± 1.4 1.9 ± 2.3 2.7 ± 2.3
Precursor B-ALL (25) 4.6 ± 2.7 3.0 ± 1.7 0.7 ± 0.8 1.1 ± 1.2 0.6 ± 0.9 0.9 ± 1.1
   - hyperdiploid (7) 2.1 ± 0.7 1.5 ± 0.2 0.7 ± 0.6 0.9 ± 1.1 0.3 ± 0.4 0.3 ± 0.3
   - EVT6/RUNX1 (10) 6.7 ± 1.7 4.4 ± 1.5 0.5 ± 1.1 0.8 ± 1.5 0.8 ± 1.1 1.1 ± 1.2
   - others (8) 4.2 ± 2.7 2.4 ± 1.3 0.9 ± 0.8 1.5 ± 0.8 0.6 ± 0.8 1.3 ± 1.2
Non-leukemic donors (6*) 3.4 ± 0.2 2.0 ± 0.4 0.5 ± 0.7 ND 0.2 ± 0.3 ND
CEM-C7H2-S-lines (6) 2.3 ± 0.1 1.8 ± 0.1 3.1 ± 0.9 ND 1.8 ± 0.4 ND
CEM-C7H2-R-lines (6) 2.7 ± 0.3 1.8 ± 0.1 2.0 ± 2.0 ND 1.6 ± 1.3 ND
  1. 1Expression and regulation of PFKFB2 in ChALL patients, non-leukemic controls (adult healthy donors and epileptic children) and sensitive (S) and resistant (R) CEM-C7H2 cell lines. Basal mean expression, before GC-treatment, is reported as mE-value ± SD; mean regulation was assessed after 6 and 24 hours and is expressed as mM-value ± SD. The total number of cases is reported in brackets next to the subgroup name. Data were assessed by analysis of Affymetrix HGU133 plus 2.0 microarrays. Abbreviation: ND, not determined.