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Table 4 Modifying effect of estrogen-related factors on the association between SNPs and mammographic density

From: Polymorphisms in genes involved in the estrogen pathway and mammographic density

SNP reference

  

Adjusted mean mammographic density (95% CI) a

Gene name

ID b

Genotype

N (%)

Percent density (%)

Absolute density (cm2) c

Parity:

  

No

Yes

No

Yes

No

Yes

COMT

rs4680

GG

44 (6.1)

143 (19.7)

43.1 (37.1-49.1)

42.0 (38.7-45.3)

43.3 (35.7-51.7)

48.8 (44.3-53.6)

  

GA

96 (13.2)

275 (38.0)

45.3 (41.3-49.3)

43.3 (41.0-45.7)

46.4 (41.1-52.1)

46.7 (43.5-50.1)

  

AA

34 (4.7)

133 (18.3)

43.4 (36.7-50.0)

38.6 (35.2-42.0)

52.6 (43.3-62.9)

43.6 (39.3-48.2)

  

P trend d

  

0.93

0.17

0.15

0.12

  

P i e

  

0.47

0.05

CYP1B1

rs1056836

CC

53 (7.3)

163 (22.4)

46.6 (41.1-52.1)

42.8 (39.7-45.8)

54.2 (46.4-62.7)

47.2 (43.1-51.5)

  

GC

86 (11.8)

282 (38.8)

46.3 (42.0-50.5)

41.8 (39.5-44.1)

47.0 (41.3-53.0)

46.4 (43.3-49.6)

  

GG

35 (4.8)

108 (14.8)

36.9 (30.3-43.5)

40.6 (36.8-44.3)

37.0 (29.5-45.4)

45.5 (40.6-50.7)

  

P trend

  

0.04

0.38

0.004

0.62

  

P i

  

0.19

0.02

Hormonal derivatives used:

No

Yes

No

Yes

No

Yes

HSD17B1

rs598126

CC

14 (1.9)

177 (24.5)

38.3 (27.7-49.0)

43.0 (40.1-45.9)

38.1 (26.3-52.4)

49.3 (45.2-53.5)

  

CT

24 (3.3)

326 (45.2)

44.2 (36.2-52.2)

43.0 (40.9-45.2)

45.4 (35.2-56.9)

46.6 (43.7-49.7)

  

TT

16 (2.2)

165 (22.9)

52.0 (42.1-61.8)

39.9 (36.9-42.9)

56.6 (42.6-72.7)

43.1 (39.2-47.2)

  

P trend

  

0.06

0.16

0.06

0.04

  

P i

  

0.03

0.02

HSD17B1

rs2010750

GG

15 (2.1)

218 (30.1)

38.2 (27.9-48.5)

43.1 (40.5-45.8)

37.9 (26.5-51.7)

48.2 (44.6-52.0)

  

AG

25 (3.5)

322 (44.5)

44.7 (36.8-52.5)

42.9 (40.8-45.1)

45.8 (35.8-57.2)

47.4 (44.4-50.4)

  

AA

15 (2.1)

129 (17.8)

52.9 (42.8-63.0)

39.6 (36.2-43.0)

58.7 (44.1-75.7)

42.4 (38.0-47.0)

  

P trend

  

0.04

0.16

0.04

0.08

  

P i

  

0.02

0.01

COMT

rs4680

GG

15 (2.1)

172 (23.7)

47.5 (37.3-57.6)

41.8 (38.9-44.8)

55.0 (40.9-71.4)

47.0 (43.0-51.2)

  

GA

29 (4.0)

342 (47.1)

49.1 (41.7-56.6)

43.3 (41.2-45.4)

50.2 (40.2-61.5)

46.1 (43.3-49.0)

  

AA

11 (1.5)

156 (21.5)

31.8 (20.1-43.6)

40.2 (37.1-43.3)

30.6 (19.4-44.9)

46.6 (42.5-51.0)

  

P trend

  

0.07

0.50

0.02

0.93

  

P i

  

0.12

0.03

Age at menarche (median) (years):

≤12

> 12

≤12

> 12

≤12

> 12

COMT

rs4680

GG

76 (10.8)

108 (15.3)

41.2 (36.7-45.6)

43.7 (39.9-47.5)

42.7 (37.0-48.8)

51.6 (46.2-57.2)

  

GA

165 (23.3)

196 (27.7)

43.0 (40.0-46.1)

43.9 (41.1-46.7)

48.7 (44.5-53.1)

43.7 (40.1-47.5)

  

AA

73 (10.3)

89 (12.6)

40.8 (36.2-45.4)

38.2 (34.1-42.4)

47.9 (41.7-54.6)

43.4 (38.1-49.0)

  

P trend

  

0.93

0.06

0.22

0.03

  

P i

  

0.25

0.02

Body mass index (median) (kg/m 2 ):

≤24.4

> 24.4

≤24.4

> 24.4

≤24.4

> 24.4

HSD17B1

rs598126

CC

91 (12.6)

100 (13.9)

49.8 (45.5-54.1)

34.5 (30.4-38.6)

49.1 (43.3-55.2)

47.1 (41.7-52.9)

  

CT

188 (26.0)

162 (22.4)

51.3 (48.3-54.3)

34.7 (31.5-38.0)

50.0 (45.8-54.3)

43.7 (39.5-48.0)

  

TT

92 (12.7)

89 (12.3)

52.3 (48.0-56.6)

29.1 (24.7-33.4)

51.9 (45.9-58.2)

37.2 (32.2-42.6)

  

P trend

  

0.42

0.08

0.53

0.01

  

P i

  

0.07

0.02

  1. a Analyses are adjusted for age at mammography, body mass index, waist-to-hip ratio, height, age at menarche, number of breast biopsies, family history of breast cancer, past contraceptive and hormone replacement therapy uses, smoking status, energy and alcohol intakes, physical activity and education when applicable. Except for modifying effect of parity, models were also adjusted for age at first birth, number of full-term pregnancies and breastfeeding. CI: confidence interval.
  2. b SNPs: single nucleotide polymorphisms. They are identified by their dbSNP accession number at http://www.ncbi.nlm.nih.gov/SNP/.
  3. c Means of absolute density are presented as back-transformed values.
  4. d P value is the P trend, testing genotype dosage, number of copies of the rare allele entered as 0, 1, 2 and mammographic density entered as a continuous variable.
  5. e P value for interaction between the variable (parity, hormonal derivative used, age at menarche or body mass index) and the genotype dosage from linear regression.
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BMC Cancer

ISSN: 1471-2407

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