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Table 4 Modifying effect of estrogen-related factors on the association between SNPs and mammographic density

From: Polymorphisms in genes involved in the estrogen pathway and mammographic density

SNP reference    Adjusted mean mammographic density (95% CI) a
Gene name ID b Genotype N (%) Percent density (%) Absolute density (cm2) c
Parity:    No Yes No Yes No Yes
COMT rs4680 GG 44 (6.1) 143 (19.7) 43.1 (37.1-49.1) 42.0 (38.7-45.3) 43.3 (35.7-51.7) 48.8 (44.3-53.6)
   GA 96 (13.2) 275 (38.0) 45.3 (41.3-49.3) 43.3 (41.0-45.7) 46.4 (41.1-52.1) 46.7 (43.5-50.1)
   AA 34 (4.7) 133 (18.3) 43.4 (36.7-50.0) 38.6 (35.2-42.0) 52.6 (43.3-62.9) 43.6 (39.3-48.2)
   P trend d    0.93 0.17 0.15 0.12
   P i e    0.47 0.05
CYP1B1 rs1056836 CC 53 (7.3) 163 (22.4) 46.6 (41.1-52.1) 42.8 (39.7-45.8) 54.2 (46.4-62.7) 47.2 (43.1-51.5)
   GC 86 (11.8) 282 (38.8) 46.3 (42.0-50.5) 41.8 (39.5-44.1) 47.0 (41.3-53.0) 46.4 (43.3-49.6)
   GG 35 (4.8) 108 (14.8) 36.9 (30.3-43.5) 40.6 (36.8-44.3) 37.0 (29.5-45.4) 45.5 (40.6-50.7)
   P trend    0.04 0.38 0.004 0.62
   P i    0.19 0.02
Hormonal derivatives used: No Yes No Yes No Yes
HSD17B1 rs598126 CC 14 (1.9) 177 (24.5) 38.3 (27.7-49.0) 43.0 (40.1-45.9) 38.1 (26.3-52.4) 49.3 (45.2-53.5)
   CT 24 (3.3) 326 (45.2) 44.2 (36.2-52.2) 43.0 (40.9-45.2) 45.4 (35.2-56.9) 46.6 (43.7-49.7)
   TT 16 (2.2) 165 (22.9) 52.0 (42.1-61.8) 39.9 (36.9-42.9) 56.6 (42.6-72.7) 43.1 (39.2-47.2)
   P trend    0.06 0.16 0.06 0.04
   P i    0.03 0.02
HSD17B1 rs2010750 GG 15 (2.1) 218 (30.1) 38.2 (27.9-48.5) 43.1 (40.5-45.8) 37.9 (26.5-51.7) 48.2 (44.6-52.0)
   AG 25 (3.5) 322 (44.5) 44.7 (36.8-52.5) 42.9 (40.8-45.1) 45.8 (35.8-57.2) 47.4 (44.4-50.4)
   AA 15 (2.1) 129 (17.8) 52.9 (42.8-63.0) 39.6 (36.2-43.0) 58.7 (44.1-75.7) 42.4 (38.0-47.0)
   P trend    0.04 0.16 0.04 0.08
   P i    0.02 0.01
COMT rs4680 GG 15 (2.1) 172 (23.7) 47.5 (37.3-57.6) 41.8 (38.9-44.8) 55.0 (40.9-71.4) 47.0 (43.0-51.2)
   GA 29 (4.0) 342 (47.1) 49.1 (41.7-56.6) 43.3 (41.2-45.4) 50.2 (40.2-61.5) 46.1 (43.3-49.0)
   AA 11 (1.5) 156 (21.5) 31.8 (20.1-43.6) 40.2 (37.1-43.3) 30.6 (19.4-44.9) 46.6 (42.5-51.0)
   P trend    0.07 0.50 0.02 0.93
   P i    0.12 0.03
Age at menarche (median) (years): ≤12 > 12 ≤12 > 12 ≤12 > 12
COMT rs4680 GG 76 (10.8) 108 (15.3) 41.2 (36.7-45.6) 43.7 (39.9-47.5) 42.7 (37.0-48.8) 51.6 (46.2-57.2)
   GA 165 (23.3) 196 (27.7) 43.0 (40.0-46.1) 43.9 (41.1-46.7) 48.7 (44.5-53.1) 43.7 (40.1-47.5)
   AA 73 (10.3) 89 (12.6) 40.8 (36.2-45.4) 38.2 (34.1-42.4) 47.9 (41.7-54.6) 43.4 (38.1-49.0)
   P trend    0.93 0.06 0.22 0.03
   P i    0.25 0.02
Body mass index (median) (kg/m 2 ): ≤24.4 > 24.4 ≤24.4 > 24.4 ≤24.4 > 24.4
HSD17B1 rs598126 CC 91 (12.6) 100 (13.9) 49.8 (45.5-54.1) 34.5 (30.4-38.6) 49.1 (43.3-55.2) 47.1 (41.7-52.9)
   CT 188 (26.0) 162 (22.4) 51.3 (48.3-54.3) 34.7 (31.5-38.0) 50.0 (45.8-54.3) 43.7 (39.5-48.0)
   TT 92 (12.7) 89 (12.3) 52.3 (48.0-56.6) 29.1 (24.7-33.4) 51.9 (45.9-58.2) 37.2 (32.2-42.6)
   P trend    0.42 0.08 0.53 0.01
   P i    0.07 0.02
  1. a Analyses are adjusted for age at mammography, body mass index, waist-to-hip ratio, height, age at menarche, number of breast biopsies, family history of breast cancer, past contraceptive and hormone replacement therapy uses, smoking status, energy and alcohol intakes, physical activity and education when applicable. Except for modifying effect of parity, models were also adjusted for age at first birth, number of full-term pregnancies and breastfeeding. CI: confidence interval.
  2. b SNPs: single nucleotide polymorphisms. They are identified by their dbSNP accession number at http://www.ncbi.nlm.nih.gov/SNP/.
  3. c Means of absolute density are presented as back-transformed values.
  4. d P value is the P trend, testing genotype dosage, number of copies of the rare allele entered as 0, 1, 2 and mammographic density entered as a continuous variable.
  5. e P value for interaction between the variable (parity, hormonal derivative used, age at menarche or body mass index) and the genotype dosage from linear regression.