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Table 3 Associations between SNPs in genes involved in the estrogen pathway and mammographic density

From: Polymorphisms in genes involved in the estrogen pathway and mammographic density

     Mean mammographic density
     Percent density (%) (95% CI)a Absolute density (cm2)b(95% CI)
Gene name SNP reference IDc Genotype N (%)d Crude Adjustede Crude Adjustede
ERα rs2077647 TT 189 (25.96) 42.5 (39.0-46.0) 42.5 (39.7-45.4) 47.7 (43.6-51.9) 47.6 (43.8-51.7)
   TC 357 (49.04) 42.5 (40.0-45.1) 42.5 (40.5-44.6) 47.8 (44.8-50.8) 47.1 (44.3-50.0)
   CC 182 (25.00) 42.6 (39.0-46.1) 43.3 (40.4-46.3) 45.5 (41.5-49.7) 44.8 (40.9-48.8)
   P trend f   0.98 0.69 0.48 0.31
  rs2234693 AA 211 (28.71) 41.6 (38.3-44.8) 42.3 (39.5-45.0) 48.0 (44.1-52.0) 48.3 (44.6-52.2)
   AG 350 (47.62) 42.6 (40.1-45.2) 42.1 (40.0-44.2) 47.6 (44.7-50.7) 46.7 (43.9-49.7)
   GG 174 (23.67) 42.7 (39.1-46.3) 43.7 (40.7-46.7) 45.2 (41.1-49.4) 44.3 (40.4-48.4)
   P trend   0.63 0.50 0.35 0.16
  rs9340799 AA 301 (40.95) 42.1 (39.3-44.8) 42.7 (40.5-45.0) 49.1 (45.8-52.5) 49.4 (46.2-52.6)
   AG 327 (44.49) 42.2 (39.6-44.9) 41.8 (39.6-43.9) 45.8 (42.8-49.0) 44.6 (41.7-47.5)
   GG 107 (14.56) 43.9 (39.3-48.5) 44.9 (41.1-48.7) 46.6 (41.4-52.2) 46.2 (41.2-51.6)
   P trend   0.58 0.58 0.26 0.11
  rs2228480 CC 508 (69.02) 41.5 (39.4-43.6) 42.0 (40.3-43.8) 46.3 (43.9-48.9) 46.1 (43.8-48.5)
   CT 207 (28.13) 44.4 (41.1-47.7) 43.4 (40.7-46.1) 48.6 (44.7-52.6) 46.9 (43.2-50.8)
   TT 21 (2.85) 43.0 (32.6-53.4) 47.3 (38.7-55.9) 53.2 (40.9-67.2) 56.6 (44.3-70.5)
   P trend   0.20 0.20 0.19 0.25
ERβ rs3829768 TT 733 (99.73) 42.4 (40.6-44.1) 42.6 (41.2-44.0) 47.2 (45.1-49.3) 46.7 (44.7-48.7)
   TC 2(0.27) 30.3 (-3.4-64.0) 16.5 (-11.2-44.2) 45.6 (15.9-94.2) 34.0 (10.6-74.7)
   P trend   0.48 0.07 0.94 0.48
  rs1256049 GG 688 (93.35) 42.6 (40.8-44.4) 42.8 (41.3-44.2) 47.4 (45.3-49.6) 46.9 (44.8-48.9)
   GA 48 (6.51) 38.9 (32.0-45.8) 40.0 (34.3-45.6) 44.2 (36.7-52.4) 44.5 (37.3-52.5)
   AA 1 (0.14) 43.0 (-4.7-90.7)   54.1 (12.1-133.8)  
   P trend   0.33 0.35 0.50 0.57
HSD17B1 rs676387 GG 390 (52.92) 42.2 (39.8-44.6) 41.7 (39.8-43.7) 46.2 (43.4-49.0) 45.1 (42.5-47.8)
   GT 288 (39.08) 42.8 (40.0-45.6) 43.4 (41.1-45.7) 48.4 (45.1-51.8) 48.4 (45.2-51.7)
   TT 59 (8.01) 40.1 (33.9-46.3) 42.6 (37.4-47.9) 46.4 (39.5-54.0) 47.3 (40.4-54.8)
   P trend   0.83 0.39 0.53 0.20
  rs598126 CC 195 (26.64) 41.2 (37.8-44.7) 42.6 (39.8-45.5) 48.2 (44.2-52.4) 48.4 (44.5-52.5)
   CT 354 (48.36) 43.7 (41.1-46.2) 43.1 (41.0-45.2) 47.6 (44.6-50.6) 46.6 (43.8-49.5)
   TT 183 (25.00) 40.5 (37.0-44.1) 41.0 (38.1-43.9) 44.5 (40.6-48.6) 44.3 (40.5-48.3)
   P trend   0.81 0.44 0.21 0.15
  rs2010750 GG 237 (32.29) 41.9 (38.8-45.0) 42.8 (40.3-45.4) 47.7 (44.1-51.5) 47.5 (44.0-51.1)
   GA 351 (47.82) 43.6 (41.0-46.1) 43.1 (41.0-45.1) 48.0 (45.0-51.1) 47.3 (44.5-50.2)
   AA 146 (19.89) 40.2 (36.3-44.2) 41.0 (37.7-44.2) 44.2 (39.9-48.8) 44.0 (39.7-48.4)
   P trend   0.67 0.46 0.30 0.26
COMT rs4680 GG 190 (25.85) 43.1 (39.6-46.6) 42.4 (39.5-45.3) 48.0 (44.0-52.2) 47.7 (43.8-51.8)
   GA 375 (51.02) 43.3 (40.8-45.8) 43.8 (41.7-45.8) 47.1 (44.3-50.1) 46.5 (43.7-49.3)
   AA 170 (23.13) 39.0 (35.3-42.6) 39.6 (36.6-42.6) 45.7 (41.6-50.1) 45.4 (41.5-49.6)
   P trend   0.12 0.21 0.45 0.43
CYP1B1 rs1056836 CC 219 (29.72) 43.7 (40.4-46.9) 43.7 (41.0-46.3) 49.6 (45.8-53.6) 48.8 (45.2-52.6)
   CG 372 (50.47) 42.3 (39.8-44.8) 42.8 (40.8-44.8) 46.7 (43.8-49.6) 46.4 (43.7-49.2)
   GG 146 (19.81) 40.2 (36.2-44.1) 39.8 (36.6-43.1) 44.2 (39.9-48.9) 43.6 (39.4-48.0)
   P trend   0.18 0.09 0.07 0.08
  1. a CI: confidence interval. b Means of absolute density are presented as back-transformed values.
  2. c SNPs: single nucleotide polymorphisms. They are identified by their dbSNP accession number at http://www.ncbi.nlm.nih.gov/SNP/.
  3. d N (%) values are slightly lower in adjusted models because of ten missing values in adjustment variables. e Adjusted for age at mammography, body mass index, waist-to-hip ratio, height, age at menarche, age at first birth, number of full-term pregnancies, breastfeeding, number of breast biopsies, family history of breast cancer, past contraceptive and hormone replacement therapy uses, smoking status, energy and alcohol intakes, physical activity and education. f P value is the P trend, testing genotype dosage, number of copies of the rare allele entered as 0, 1, 2 and mammographic density entered as continuous variable.