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Table 3 Clinic and pathologic findings in 130 patients with CM, according to CAF-1/p60 expression in radial and vertical growth phase.

From: Overexpression of Chromatin Assembly Factor-1/p60 helps to predict the prognosis of melanoma patients

CLINICO-PATHOLOGIC FEATURES

 

CAF-1/P60 radial growth phase

CAF-1/P60 vertical growth phase

 

N°

+

%

++

%

+++

%

PVALUE°

+

%

++

%

+++

%

PVALUE°

AGE

               

≤30

13

9

69,2%

4

30,8%

0

0

NS

3

23,0%

6

46,2%

4

30,8%

NS

>30

117

82

70,0%

35

30%

0

0

NS

44

37,6%

40

34,2%

33

28,2%

NS

STAGING

               

IA

25

22

88,0%

3

12,0%

0

0

<0,001

19

76,0%

3

12,0%

3

12,0%

<0,001

IB

45

42

93,3%

3

6,7%

0

0

<0,001

19

42,2%

24

53,3%

2

4,5%

<0,001

IIA

28

20

71,4%

8

28,6%

0

0

<0,001

9

32,1%

12

42,8%

7

25,1%

<0,001

IIB

16

3

18,7%

13

81,3%

0

0

<0,001

0

0

3

18,7%

13

81,3%

<0,001

IIC

4

3

75,0%

1

25,0%

0

0

<0,001

0

0

1

25,0%

3

75,0%

<0,001

IIIA

4

1

25,0%

3

75,0%

0

0

<0,001

0

0

1

25,0%

3

75,0%

<0,001

IIIB

7

0

0

7

100%

0

0

<0,001

0

0

0

0

7

100%

<0,001

IV

1

0

0

1

100%

0

0

<0,001

0

0

0

0

1

100%

<0,001

BRESLOW

               

<1 mm

28

25

89,3%

3

10,7%

0

0

<0,001

19

67,8%

6

21,4%

3

10,8%

<0,001

1.01-2.00 mm

51

41

80,4%

10

19,6%

0

0

<0,001

21

41,2%

22

43,1%

8

15,7%

<0,001

2.01-4.00 mm

41

21

51,2%

20

48,8%

0

0

<0,001

7

17,1%

14

34,1%

20

48,8%

<0,001

>4.00 mm

10

4

40,0%

6

60,0%

0

0

<0,001

0

0

4

40,0%

6

60,0%

<0,001

PROGNOSIS

               

NO PROGRESSION

95

91

95,8%

4

4,2%

0

0

<0,001

47

49,5%

46

48,4%

2

2,1%

<0,001

S/N/M*

35

0

0

35

100%

0

0

<0,001

0

0

0

0

35

100%

<0,001

  1. *S: skin (dermal/hypodermal) metastasis; N: nodal metastasis; M: distant metastasis; °(P value were calculated by t-test or ANOVA)