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Table 2 GO enrichment analysis of genes that correlated to the quantified metabolites, using GOrilla.

From: Merging transcriptomics and metabolomics - advances in breast cancer profiling

Metabolite/GO-category GO-Term Description P-value Enrichment (N,B,n,b)
   BP GO:0032502 developmental process 6.40E-10 1.45 (7307,1397,864,240)
   BP GO:0030198 extracellular matrix organization 1.00E-09 7.16 (7307,56,310,17)
   BP GO:0007155 cell adhesion 1.20E-08 2.45 (7307,377,412,52)
   BP GO:0022610 biological adhesion 1.40E-08 2.44 (7307,378,412,52)
   BP GO:0043062 extracellular structure organization 2.20E-07 4.92 (7307,86,311,18)
   MF GO:0005201 extracellular matrix structural constituent 2.10E-09 7.39 (7307,51,310,16)
   CC GO:0005576 extracellular region 3.80E-21 2.76 (7307,885,311,104)
   CC GO:0044421 extracellular region part 7.10E-17 2.28 (7307,513,757,121)
   CC GO:0031012 extracellular matrix 5.30E-15 5.34 (7307,159,310,36)
   CC GO:0005578 proteinaceous extracellular matrix 2.90E-14 5.57 (7307,142,305,33)
   CC GO:0044420 extracellular matrix part 2.30E-10 3.44 (7307,71,986,33)
   CC GO:0005581 collagen 1.60E-08 21.83 (7307,26,103,8)
   BP GO:0032502 developmental process 8.20E-08 1.48 (7307,1397,630,178)
   BP GO:0048731 system development 1.90E-07 2.23 (7307,314,554,53)
   MF GO:0005201 extracellular matrix structural constituent 6.20E-10 16.25 (7307,51,97,11)
   CC GO:0044421 extracellular region part 8.30E-14 2.44 (7307,513,485,83)
   CC GO:0005576 extracellular region 3.90E-12 2.35 (7307,885,267,76)
   CC GO:0031012 extracellular matrix 2.60E-10 3.43 (7307,159,482,36)
   CC GO:0044420 extracellular matrix part 1.80E-09 12.73 (7307,71,97,12)
   CC GO:0005578 proteinaceous extracellular matrix 2.10E-09 3.52 (7307,142,482,33)
   CC GO:0005581 collagen 5.10E-08 9.48 (7307,26,326,11)
   BP GO:0090304 nucleic acid metabolic process 2.00E-09 1.75 (7307,497,990,118)
   BP GO:0022402 cell cycle process 2.30E-08 2.09 (7307,239,952,65)
   BP GO:0007059 chromosome segregation 3.90E-07 4.65 (7307,25,943,15)
   BP GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 8.80E-07 1.54 (7307,640,994,134)
   CC GO:0044428 nuclear part 9.80E-11 1.7 (7307,632,999,147)
   CC GO:0005634 nucleus 5.80E-09 1.3 (7307,2062,990,364)
   CC GO:0000775 chromosome, centromeric region 2.50E-08 10.2 (7307,26,303,11)
   BP GO:0002376 immune system process 1.60E-09 1.83 (7307,420,999,105)
   MF GO:0000030 mannosyltransferase activity 5.80E-08 73.81 (7307,4,99,4)
   CC GO:0070469 respiratory chain 5.80E-07 4.74 (7307,22,981,14)
  1. GO-terms in the Biological Process (BP), Molecular Function (MF) and Cellular Compartment (CC) categories that were significantly enriched (p-value < 10E-7) towards the top of the lists of transcripts ranked according to correlation to each of the quantified metabolites. Enrichment is defined as (b/n)/(B/N), where N is the total number of genes, B is the total number of genes associated with a specific GO term, n is the number of genes in the "target set", b is the number of genes in the "target set" associated with a specific GO term [21]. The p-value threshold corresponds to fdr = 8 metabolites * (877 CC GO-terms*10^-7 + 2416 MF GO-terms*10^-7 + 6307 BP GO-terms*10^-7)/31 significant GO terms = 0.003. There were no significantly enriched GO-terms associated with GPC or PCho