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Table 4 Multivariable logistic regression modeling for association of high COX-2 with increased phosphorylation of Akt, caspase-9, or BAD

From: COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer

 

OR*

95% CI

p-value

N

COX-2 and pAkt Ser473

All patients

1.52

1.05-2.09

0.024

211

ERNEG

1.47

0.84-2.57

0.181

89

ERPOS

1.57

0.96-2.57

0.072

121

HER2NEG

1.33

0.87-2.02

0.183

135

HER2POS

2.99

1.09-8.15

0.034

76

ERNEG/HER2POS

4.87

0.90-26.2

0.065

25

COX-2 and pAkt Thr308

All patients

1.99

1.31-3.02

0.001

207

ERNEG

1.85

0.98-3.50

0.057

87

ERPOS

2.08

1.18-3.63

0.011

119

HER2NEG

1.76

1.09-2.86

0.021

134

HER2POS

4.25

1.44-12.6

0.009

72

ERNEG/HER2POS

14.9

1.43-154

0.024

23

COX-2 and pCasp9 Ser196

All patients

1.90

1.36-2.65

0.000

211

ERNEG

1.84

1.06-3.22

0.030

89

ERPOS

2.01

1.31-3.08

0.001

121

HER2NEG

1.56

1.06-2.29

0.025

135

HER2POS

3.35

1.41-7.91

0.006

76

ERNEG/HER2POS

16.3

1.72-154.6

0.015

25

COX-2 and pBAD Ser136

All patients

1.61

1.20-2.16

0.001

209

ERNEG

1.58

1.04-2.38

0.032

89

ERPOS

1.66

1.09-2.54

0.019

119

HER2NEG

1.42

0.99-2.02

0.051

135

HER2POS

2.21

1.22-3.95

0.008

74

ERNEG/HER2POS

4.10

1.15-14.7

0.030

25

  1. * OR (Odds ratio) adjusted for age at diagnosis, race, TNM stage and receipt of neoadjuvant chemotherapy