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Table 2 Effects of high COX-2 expression on breast cancer survival1

From: COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer

  5-Year Multivariable Cox Regression3 10-Year Multivariable Cox Regression3
  H.R. 95% CI p-value N H.R. 95% CI p-value N
All patients 1.82 1.07-3.10 0.028* 184 1.60 0.96-2.65 0.066 184
ER-negative 2.79 1.35-5.78 0.006* 81 2.72 1.36-5.41 0.004* 81
ER-positive 1.26 0.53-2.99 0.598 103 0.96 0.42-2.21 0.920 103
HER2-negative 1.50 0.77-2.94 0.237 121 1.37 0.73-2.56 0.331 121
HER2-positive2 3.39 1.24-9.21 0.017* 62 2.84 1.07-7.52 0.036* 62
ER-/HER2- 2.47 1.00-6.10 0.048* 61 2.34 1.01-5.41 0.047* 61
ER-/HER2+ 5.95 1.01-34.9 0.048* 20 5.953 1.01-34.9 0.048* 20
ER+/HER2- 0.73 0.21-2.58 0.626 60 0.64 0.18-2.20 0.474 60
ER+/HER2+ 2.60 0.47-14.2 0.272 42 1.91 0.42-8.57 0.397 42
  1. 1 High COX-2 expression (moderate to strong IHC) versus low COX-2 expression (absent to weak IHC).
  2. 2 HER2-positive: moderate to high IHC. 3 Adjusted for age at diagnosis, race, TNM stage, tumor grade, chemotherapy and tumor ER and p53 mutation status. 3 No further deaths after 5 years. *p < 0.05