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Figure 5 | BMC Cancer

Figure 5

From: COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer

Figure 5

Effect of ER/HER2 strata on COX-2 associated breast cancer survival. Kaplan-Meier cumulative breast cancer specific survival curves of (A) ER-negative and low HER2 expressing breast cancer patients by tumor COX-2 status (n = 70). The survival of patients with high COX-2 expression (n = 25) was significantly poorer than the survival of patients with low COX-2 expression (n = 45). Log-rank test: p = 0.044. (B) ER-negative and high HER2 expressing breast cancer patients by tumor COX-2 status (n = 28). The survival of patients with high COX-2 expression (n = 10) was significantly poorer than the survival of patients with low COX-2 expression (n = 18). Log-rank test: p = 0.006. (C) ER-positive and low HER2 expressing breast cancer patients by tumor COX-2 status (n = 77). The survival of patients with high COX-2 expression (n = 28) was not significantly different from the survival of patients with low COX-2 expression (n = 49). Log-rank test: p = 0.182. (D) ER-positive and high HER2 expressing breast cancer patients by tumor COX-2 status (n = 61). The survival of patients with high COX-2 expression (n = 22) was not significantly different from the survival of patients with low COX-2 expression (n = 39). Log-rank test: p = 0.383.

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