Figure 4

Association between COX-2 and breast cancer survival by ER and HER2 status. Kaplan-Meier cumulative breast cancer-specific survival curves of (A) ER-negative breast cancer patients by tumor COX-2 status (n = 98). The survival of patients with high COX-2 expression (n = 35) was significantly poorer than the survival of patients with low COX-2 expression (n = 63). Log-rank test: p = 0.001. (B) ER-positive breast cancer patients by tumor COX-2 status (n = 139). The survival of patients with high COX-2 expression (n = 51) was not significantly different from the survival of patients with low COX-2 expression (n = 88). Log-rank test: p = 0.483. (C) Low HER2 expressing breast cancer patients by tumor COX-2 status (n = 154). The survival of patients with high COX-2 expression (n = 54) was not significantly different from the survival of patients with low COX-2 expression (n = 100). Log-rank test: p = 0.601. (D) High HER2 expressing breast cancer patients by tumor COX-2 status (n = 93). The survival of patients with high COX-2 expression (n = 35) was significantly poorer than the survival of patients with low COX-2 expression (n = 58). Log-rank test: p = 0.022.