Racial differences in treatment and survival in older patients with diffuse large B-cell lymphoma (DLBCL)

Griffiths, Robert; Gleeson, Michelle; Knopf, Kevin; Danese, Mark

doi:10.1186/1471-2407-10-625

BMC Cancer

Table 2 Multivariate Analysis of Treatment

From: Racial differences in treatment and survival in older patients with diffuse large B-cell lymphoma (DLBCL)

		Time to Treatment - Overall				Time to Treatment - Stage I & II				Time to Treatment - Stage III & IV				Treatment within 180 days
		HR	p-value	95% CI		HR	p-value	95% CI		HR	p-value	95% CI		OR	p-value	95% CI
Age
	64-< 70	ref.
	70-< 75	1.00	0.91	0.91	1.08	0.90	0.07	0.79	1.01	1.10	0.16	0.96	1.24	0.73	0.01	0.59	0.91
	75-< 80	0.95	0.20	0.87	1.03	0.91	0.12	0.81	1.03	0.99	0.86	0.87	1.12	0.59	< 0.0001	0.48	0.73
	≥ 80	0.78	< 0.0001	0.72	0.84	0.69	< 0.0001	0.62	0.77	0.89	0.07	0.79	1.01	0.38	< 0.0001	0.31	0.46
Gender
	Female	ref.
	Male	0.99	0.70	0.94	1.04	1.01	0.83	0.94	1.09	0.97	0.42	0.89	1.05	0.85	0.01	0.76	0.95
Race
	White	ref
	Black	0.77	< 0.001	0.66	0.89	0.76	0.01	0.61	0.95	0.76	0.02	0.60	0.96	0.63	< 0.01	0.47	0.85
	other	1.01	0.78	0.92	1.12	1.06	0.42	0.92	1.21	0.95	0.57	0.81	1.12	0.99	0.89	0.79	1.22
Histology
	9680	ref
	9684	0.86	0.10	0.71	1.03	0.70	0.01	0.53	0.92	1.16	0.27	0.89	1.50	0.66	0.03	0.45	0.95
Stage at diagnosis
	I	ref
	II	1.20	< 0.0001	1.11	1.29	1.21	< 0.0001	1.12	1.30					1.32	< 0.01	1.11	1.58
	III	1.27	< 0.0001	1.17	1.38									1.04	0.71	0.86	1.26
	IV	1.23	< 0.0001	1.14	1.32					0.93	0.37	0.80	1.08	0.91	0.22	0.78	1.06
	unknown	0.85	0.01	0.75	0.96									0.56	< 0.0001	0.44	0.71
NCI Comorbidity Index
	0	ref
	1	1.05	0.15	0.98	1.12	1.03	0.53	0.94	1.13	1.09	0.07	0.99	1.20	1.00	0.95	0.86	1.15
	2	1.03	0.51	0.94	1.14	1.03	0.64	0.90	1.18	1.09	0.24	0.94	1.26	0.87	0.19	0.71	1.07
	≥3	0.93	0.25	0.82	1.05	1.04	0.64	0.88	1.24	0.89	0.25	0.73	1.09	0.56	< 0.0001	0.44	0.71
Year of diagnosis
	2001	ref
	2002	0.99	0.84	0.91	1.08	0.95	0.35	0.84	1.06	1.08	0.25	0.95	1.23	0.95	0.57	0.79	1.14
	2003	1.04	0.37	0.96	1.13	1.00	0.99	0.89	1.12	1.10	0.14	0.97	1.25	1.18	0.08	0.98	1.42
	2004	1.03	0.53	0.95	1.12	1.00	0.98	0.89	1.12	1.04	0.51	0.92	1.19	1.17	0.09	0.98	1.41
	2005	0.99	0.89	0.91	1.08	0.93	0.26	0.83	1.05	1.08	0.24	0.95	1.22	1.00	0.99	0.83	1.20
Percent of 25+ year olds in census tract with some college
	0-< 25%	ref
	25-< 50%	0.95	0.11	0.89	1.01	0.91	0.03	0.83	0.99	0.96	0.39	0.87	1.06	0.92	0.25	0.80	1.06
	≥50%	0.84	0.34	0.59	1.20	0.87	0.61	0.52	1.46	0.87	0.68	0.45	1.70	0.50	0.04	0.26	0.98
Percent living in poverty in census tract
	0-< 5%	ref
	5-< 7%	0.92	0.04	0.84	1.00	0.94	0.31	0.84	1.06	0.92	0.18	0.81	1.04	0.87	0.15	0.73	1.05
	7-< 12%	0.97	0.36	0.90	1.04	0.95	0.32	0.86	1.05	0.97	0.54	0.86	1.08	0.95	0.51	0.80	1.12
	≥12%	0.90	0.01	0.83	0.97	0.92	0.10	0.82	1.02	0.89	0.04	0.79	1.00	0.82	0.02	0.70	0.97
SEER region
	CA	ref
	CT	1.05	0.40	0.93	1.19	1.01	0.87	0.86	1.20	1.10	0.33	0.91	1.32	1.14	0.34	0.87	1.50
	Detroit	0.99	0.84	0.89	1.10	0.96	0.57	0.82	1.12	1.09	0.32	0.92	1.28	1.07	0.61	0.83	1.37
	HI	0.95	0.65	0.74	1.21	0.90	0.54	0.65	1.25	1.01	0.95	0.68	1.50	1.07	0.81	0.62	1.85
	IA	1.16	0.01	1.05	1.29	1.31	< 0.001	1.13	1.51	1.04	0.67	0.88	1.22	1.44	< 0.01	1.12	1.86
	NM	1.17	0.09	0.98	1.39	1.23	0.10	0.96	1.58	1.11	0.47	0.84	1.47	0.92	0.68	0.64	1.35
	Seattle	1.01	0.93	0.89	1.13	1.08	0.40	0.91	1.28	0.97	0.72	0.82	1.15	1.29	0.07	0.98	1.70
	UT	0.93	0.32	0.80	1.08	0.91	0.34	0.75	1.11	0.99	0.90	0.79	1.24	0.90	0.52	0.65	1.24
	Atlanta	1.08	0.38	0.91	1.27	1.05	0.71	0.82	1.35	1.09	0.47	0.86	1.40	1.16	0.45	0.79	1.69
	Rural GA	1.04	0.89	0.62	1.73	0.76	0.47	0.36	1.61	1.32	0.54	0.54	3.22	0.84	0.72	0.31	2.27
	KY	0.95	0.37	0.86	1.06	1.00	0.95	0.87	1.16	0.96	0.58	0.81	1.13	0.91	0.42	0.73	1.14
	LA	1.06	0.33	0.95	1.18	1.01	0.88	0.87	1.18	1.18	0.06	0.99	1.41	1.09	0.51	0.85	1.39
	NJ	1.05	0.32	0.96	1.14	1.05	0.48	0.93	1.18	1.05	0.51	0.91	1.20	0.96	0.65	0.79	1.16
Lymph node site
	Nodal	ref.
	Extra-nodal	0.90	< 0.01	0.85	0.97	0.90	< 0.01	0.83	0.96	0.95	0.55	0.81	1.12	0.88	0.09	0.75	1.02
Other conditions
	Anemia	1.04	0.42	0.95	1.14	1.04	0.60	0.90	1.19	1.02	0.83	0.88	1.17	0.67	< 0.0001	0.55	0.80
	Neutropenia	1.03	0.93	0.56	1.87	0.47	0.19	0.15	1.46	1.51	0.38	0.61	3.75	0.54	0.28	0.18	1.65
	Thrombocytopenia	1.35	0.07	0.97	1.88	1.88	0.02	1.12	3.17	0.97	0.88	0.61	1.54	0.51	0.04	0.27	0.97
	Cardiovascular disease	0.99	0.77	0.89	1.09	1.01	0.86	0.88	1.16	0.93	0.33	0.79	1.08	0.93	0.49	0.76	1.14

HR: Hazard Ratio
OR: Odds Ratio

Back to article page

ISSN: 1471-2407

Contact us

Submission enquiries: bmccancer@biomedcentral.com
General enquiries: ORSupport@springernature.com