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Table 2 Details of the primary outcome measures and the measurement tools used.

From: Design of the Quality of Life in Motion (QLIM) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of a combined physical exercise and psychosocial training program to improve physical fitness in children with cancer

Primary outcome measures Measurements
Cardiorespiratory fitness Lode Corival bicycle ergometry with paediatric options; LODE BV, Groningen, the Netherlands.
Steep Ramp Test [35]
VO2 peak performance test
Muscle strength CITEC hand-held dynamometer; C.I.T. Technics BV, Haren, the Netherlands
Secondary outcome measures Measurements
Fatigue PedsQL Multidimensional Fatigue Scale Acute Version (self-report and parent-proxy report) [30]
Body composition Dual Energy X-ray Absorptiometry (DEXA) scan (Hologic QDR 4500); Hologic Bedford, USA.
Body Mass Index
Blood: calcium, phosphate, magnesium, carboxy-terminal collagen crosslinks (CTX), parathyroid hormone (PTH), serum amino-terminal procollagen 1 extension peptide (P1NP), insulin-like growth factors 1 (IGF-1), 25-hydroxy-vitamin D (25 OH vit D)
Daily physical activity levels Physical activity accelerometer: Actical 2.1; Respironics, Mini Mitter, Oregon USA
Depression Children's Depression Inventory (CDI) [32]
Quality of life PedsQL 4.0 Generic Score Scale (self-report and parent-proxy report) [30]
PedsQL 3.0 Cancer Module (self-report and parent-proxy report) [30]
Self-perception Self-Perception Profile for Children (CBSK) [31]
Self-Perception Profile for Adolescents (CBSA) [33]
Behavioural problems Child Behavior Checklist (CBCL) [34]
Youth Self-Report (YSR) [34]
Cost data Monthly cost diary
Other study outcomes Measurements
Compliance Self-report Attendance checklist for training sessions
Satisfaction with the intervention Questionnaire 11-items
Clinical data Medical record
Moderating variables Questionnaire addressing pre-illness lifestyle, current attitudes towards and beliefs about exercise, physical activity patterns.