Table 2 Details of the primary outcome measures and the measurement tools used.
Primary outcome measures | Measurements |
|---|---|
Cardiorespiratory fitness | Lode Corival bicycle ergometry with paediatric options; LODE BV, Groningen, the Netherlands. Steep Ramp Test [35] VO2 peak performance test |
Muscle strength | CITEC hand-held dynamometer; C.I.T. Technics BV, Haren, the Netherlands |
Secondary outcome measures | Measurements |
Fatigue | PedsQL Multidimensional Fatigue Scale Acute Version (self-report and parent-proxy report) [30] |
Body composition | Dual Energy X-ray Absorptiometry (DEXA) scan (Hologic QDR 4500); Hologic Bedford, USA. Body Mass Index Blood: calcium, phosphate, magnesium, carboxy-terminal collagen crosslinks (CTX), parathyroid hormone (PTH), serum amino-terminal procollagen 1 extension peptide (P1NP), insulin-like growth factors 1 (IGF-1), 25-hydroxy-vitamin D (25 OH vit D) |
Daily physical activity levels | Physical activity accelerometer: Actical 2.1; Respironics, Mini Mitter, Oregon USA |
Depression | Children's Depression Inventory (CDI) [32] |
Quality of life | PedsQL 4.0 Generic Score Scale (self-report and parent-proxy report) [30] PedsQL 3.0 Cancer Module (self-report and parent-proxy report) [30] |
Self-perception | Self-Perception Profile for Children (CBSK) [31] Self-Perception Profile for Adolescents (CBSA) [33] |
Behavioural problems | Child Behavior Checklist (CBCL) [34] Youth Self-Report (YSR) [34] |
Cost data | Monthly cost diary |
Other study outcomes | Measurements |
Compliance | Self-report Attendance checklist for training sessions |
Satisfaction with the intervention | Questionnaire 11-items |
Clinical data | Medical record |
Moderating variables | Questionnaire addressing pre-illness lifestyle, current attitudes towards and beliefs about exercise, physical activity patterns. |