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Table 4 Enriched functional gene classes in the differential expression profile of metastatic canine mammary tumors

From: Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles

Functional gene class

Gene number

Enrichment factor

up-regulated genes

  

M-phase

52

17.49

DNA replication

29

6.72

Protein folding

32

6.34

Transcription factors

48

6.21

RNA processing

50

5.99

Apoptosis

10

5.98

Mitochondrion

59

5.96

Cell cycle checkpoint

14

4.09

DNA damage response

30

3.52

Ubiquitin-pathway

13

2.56

DNA-replication initiation

7

2.05

Methyltransferases

15

1.95

RAS-signalling

5

1.71

Prefoldins

4

1.62

Transcription repressors

13

1.32

down-regulated genes

  

Transcription factors

55

3.62

mRNA processing

11

3.45

Muscle contraction

10

2.86

Transcription regulation

41

2.36

Cell growth regulation

10

2.03

Methyltransferases

6

1.75

Cell differentiation

54

1.58

Transmembrane tyrosine kinase receptors

12

1.33