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Table 4 Enriched functional gene classes in the differential expression profile of metastatic canine mammary tumors

From: Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles

Functional gene class Gene number Enrichment factor
up-regulated genes   
M-phase 52 17.49
DNA replication 29 6.72
Protein folding 32 6.34
Transcription factors 48 6.21
RNA processing 50 5.99
Apoptosis 10 5.98
Mitochondrion 59 5.96
Cell cycle checkpoint 14 4.09
DNA damage response 30 3.52
Ubiquitin-pathway 13 2.56
DNA-replication initiation 7 2.05
Methyltransferases 15 1.95
RAS-signalling 5 1.71
Prefoldins 4 1.62
Transcription repressors 13 1.32
down-regulated genes   
Transcription factors 55 3.62
mRNA processing 11 3.45
Muscle contraction 10 2.86
Transcription regulation 41 2.36
Cell growth regulation 10 2.03
Methyltransferases 6 1.75
Cell differentiation 54 1.58
Transmembrane tyrosine kinase receptors 12 1.33