Skip to main content

Table 1 Associations between TFPI- 2 promoter methylation and clinicopathological indices of NPC

From: TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma

   Promoter methylation status  
  Number of patients Methylated Unmethylated Statistic significance
Age     
   < 60 58 52(89.7%) 6 NS
   ≥ 60 12 10(83.3%) 2  
Gender     
   Male 48 44(91.7%) 4 NS
   Female 22 18(81.8%) 4  
Stage*     
   I-II 28 24(85.7%) 4 NS
   III-IV 42 38(90.5%) 4  
Histological subtype     
   Keratinizing squamous cell carcinoma 8 6(75%) 2 NS
   Non-keratinizing carcinoma 62 56(90.3%) 6  
Lymph node metastasis     
   Presence 58 50(86.2%) 8 NS
   Absence 12 12(100%) 0  
  1. *: Staging according to International Union Against Cancer (UICC).
  2. NS: not statistically significant