|  | Promoter methylation status |  | |
---|---|---|---|---|
 | Number of patients | Methylated | Unmethylated | Statistic significance |
Age | Â | Â | Â | Â |
   < 60 | 58 | 52(89.7%) | 6 | NS |
   ≥ 60 | 12 | 10(83.3%) | 2 |  |
Gender | Â | Â | Â | Â |
   Male | 48 | 44(91.7%) | 4 | NS |
   Female | 22 | 18(81.8%) | 4 |  |
Stage* | Â | Â | Â | Â |
   I-II | 28 | 24(85.7%) | 4 | NS |
   III-IV | 42 | 38(90.5%) | 4 |  |
Histological subtype | Â | Â | Â | Â |
   Keratinizing squamous cell carcinoma | 8 | 6(75%) | 2 | NS |
   Non-keratinizing carcinoma | 62 | 56(90.3%) | 6 |  |
Lymph node metastasis | Â | Â | Â | Â |
   Presence | 58 | 50(86.2%) | 8 | NS |
   Absence | 12 | 12(100%) | 0 |  |