Figure 3From: Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells MTT assay for cell viability at different time points. Anti-miR-31 alone had no effect on the proliferation of either HCT-116p53+/+ or HCT-116p53-/- cell line (p > 0.05), but when combined with 5-FU, anti-miR-31 inhibited the proliferation of both cell lines as early as 24 h after exposure to 5-FU, i.e., the optical density (OD) value of anti-miR-31 + 5-FU group was the lowest among the four groups, and the difference between anti-miR-31 + 5-FU group and negative control or anti-miR-31 group was significant (p < 0.05).Back to article page