Table 2 Results of Proton and Carbon Ion Therapy for Patients with Meningiomas
Author | Institute | Year | No. of Pts. | Radiation Modality | Overall Survival | Local Control |
|---|---|---|---|---|---|---|
Austin-Seymour et al. | MGH, Boston MA, USA | 1990 | 13 | Protons, 59,4 Gy E | 100% | 100% |
Gudjonsson et al. | Uppsala, Sweden | 1999 | 19 | Protons, 24 Gy E, 4 fractions | - | 100% at 3 years |
Wenkel et al. | MGH, Boston MA, USA | 2000 | 46 | Protons and Photons, 59.0 Gy E | 95% and 77% at 5 and 10 years | 100% and 88% at 5 and 10 years |
Hug et al. | MGH, Boston MA, USA | 2000 | 16 | Protons and Photons, 62 Gy E for atypical meningiomas, 58 Gy E for malignant meningiomas | - | 19% at 8 years for atypical meningiomas, 17% at 8 years for malignant meningiomas |
Vernimmen et al. | Tygerberg, South Africa | 2001 | 27 | Protons, 54 Gy E - 61.6 Gy E, 16 - 27 fractions | - | 88% |
Noël et al. | CPO, Orsay, France | 2002 | 17 | Protons and Photons, 61 Gy E | 88.9% at 4 years | 87.5% at 4 years |
Weber et al. | PSI, Switzerland | 2004 | 16 | Protons, 52.2-64 Gy E | 92.7% at 3 years | 91.7% at 3 years |
Noël et al. | CPO, Orsay, France | 2005 | 51 | Protons and Photons, 60.6 Gy E | 100% at 4 years | 98% at 4 years |
Combs et al. | Heidelberg, Germany | 2010 | 10 | Photons, Carbon Ion Boost | 75% and 63% at 5 and 7 years | 86% and 72% at 5 and 7 years |