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Table 2 Results of Proton and Carbon Ion Therapy for Patients with Meningiomas

From: Treatment of patients with atypical meningiomas Simpson grade 4 and 5 with a carbon ion boost in combination with postoperative photon radiotherapy: The MARCIE Trial

Author Institute Year No. of Pts. Radiation Modality Overall Survival Local Control
Austin-Seymour
et al.
MGH, Boston MA, USA 1990 13 Protons, 59,4 Gy E 100% 100%
Gudjonsson et al. Uppsala, Sweden 1999 19 Protons, 24 Gy E, 4 fractions - 100% at 3 years
Wenkel et al. MGH, Boston MA, USA 2000 46 Protons and Photons, 59.0 Gy E 95% and 77% at 5 and 10 years 100% and 88% at 5 and 10 years
Hug et al. MGH, Boston MA, USA 2000 16 Protons and Photons, 62 Gy E for atypical meningiomas, 58 Gy E for malignant meningiomas - 19% at 8 years for atypical meningiomas, 17% at 8 years for malignant meningiomas
Vernimmen et al. Tygerberg, South Africa 2001 27 Protons, 54 Gy E - 61.6 Gy E, 16 - 27 fractions - 88%
Noël et al. CPO, Orsay, France 2002 17 Protons and Photons, 61 Gy E 88.9% at 4 years 87.5% at 4 years
Weber et al. PSI, Switzerland 2004 16 Protons, 52.2-64 Gy E 92.7% at 3 years 91.7% at 3 years
Noël et al. CPO, Orsay, France 2005 51 Protons and Photons, 60.6 Gy E 100% at 4 years 98% at 4 years
Combs et al. Heidelberg, Germany 2010 10 Photons, Carbon Ion Boost 75% and 63% at 5 and 7 years 86% and 72% at 5 and 7 years