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Figure 2 | BMC Cancer

Figure 2

From: Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc

Figure 2

Oridonin induces cell cycle arrest and apoptosis. HCT116 and SW1116 cells were treated with 0, 12.5, 25 or 50 μM Oridonin for 24 hours. Cell cycle distribution was determined by flow cytometry and the representative graphs are shown in (A) and (B). Apoptosis was examined by analyzing subdiploid population (A and B, black arrow) and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay (D and F), in which at least 1,000 cells from randomly selected high-power fields were counted. Symbol * represents P < 0.05 compared with control group. The indicated proteins were detected by western blot (C and E).

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BMC Cancer

ISSN: 1471-2407

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