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Table 1 Clinical and pathological characteristics of the patients grouped by TIL density

From: High number of CD45RO+ tumor infiltrating lymphocytes is an independent prognostic factor in non-metastasized (stage I-IIA) esophageal adenocarcinoma

  CD3+ TIL
n = 99
CD8+ TIL
n = 107
CD45RO+ TIL
n = 110
Characteristics low high P-value low high P-value low high P-value
Total number of patients 42 (42.4%) 57 (57.6%)   50 (46.7%) 57 (53.3%)   17 (15.5%) 93 (84.5%)  
Gender    0.453    1.0    0.607
   male 38 (38.4%) 54 (54.5%)   46 (43.0%) 53 (49.5%)   15 (13.6%) 87 (79.1%)  
   female 4 (4.0%) 3 (3.0%)   4 (3.7%) 4 (3.7%)   2 (1.8%) 6 (5.5%)  
Tumour stage    0.298    0.688    0.353
   pT1 15 (15.3%) 26 (26.5%)   20 (18.9%) 25 (23.6%)   6 (5.5%) 42 (38.5%)  
   pT2 7 (7.1%) 12 (12.2%)   9 (8.5%) 12 (11.3%)   2 (1.8%) 18 (16.5%)  
   pT3 20 (20.4%) 18 (18.4%)   21 (19.8%) 19 (17.9%)   9 (8.3%) 32 (29.4%)  
Lymph node metastasis    0.025    0.440    0.065
   pN0 17 (17.3%) 35 (35.7%)   26 (24.5%) 31 (29.2%)   6 (5.5%) 54 (49.5%)  
   pN1 25 (25.5%) 21 (21.4%)   24 (22.6%) 25 (23.6%)   11 (10.1%) 38 (34.9%)  
Distant metastasis    0.212    0.428    0.108
   M0 37 (37.8%) 53 (54.1%)   45 (42.5%) 52 (49.1%)   14 (12.8%) 87 (79.8%)  
   M1 5 (5.1%) 3 (3.1%)   5 (4.7%) 4 (3.8%)   3 (2.8%) 5 (4.6%)  
Residual tumour    0.070    0.276    0.125
   R0 33 (34.4%) 51 (53.1%)   41 (39.4%) 51 (49.0%)   13 (12.1%) 81 (75.7%)  
   R1 8 (8.3%) 4 (4.2%)   7 (6.7%) 5 (4.8%)   4 (3.7%) 9 (8.4%)  
Grading    0.273    0.696    0.091
   G1 0 (0.0%) 2 (2.1%)   2 (1.9%) 1 (1.0%)   0 (0.0%) 5 (4.6%)  
   G2 17 (17.5%) 27 (27.8%)   20 (19.0%) 26 (24.8%)   4 (3.7%) 42 (38.9%)  
   G3 25 (25.8%) 26 (26.8%)   27 (25.7%) 29 (27.6%)   13 (12.0%) 44 (40.7%)  
UICC classification    0.086    0.776    0.156
   I 11 (11.2%) 24 (24.5%)   16 (15.1%) 23 (21.7%)   4 (3.7%) 38 (34.9%)  
   II 11 (11.2%) 19 (19.4%)   16 (15.1%) 17 (16.0%)   4 (3.7%) 28 (25.7%)  
   III 15 (15.3%) 10 (10.2%)   14 (13.2%) 12 (11.3%)   6 (5.5%) 21 (19.3%)  
   IV 5 (5.1%) 3 (3.1%)   4 (3.8%) 4 (3.8%)   3 (2.8%) 5 (4.6%)  
Recurrence of disease    0.005    0.209    0.018
   No 13 (13.3%) 33 (33.7%)   21 (19.8%) 30 (28.3%)   4 (3.7%) 50 (45.9%)  
   Yes 29 (29.6%) 23 (23.5%)   28 (26.4%) 27 (25.5%)   13 (11.9%) 42 (38.5%)