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Table 3 Workflow time table

From: Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study

Approval of ethics committee
Diagnosis of chordoma of the skull base and completion of pre-radiation treatment examinations (biopsy, operation, staging)
Informed consent of the patient and patient registration by the study office at HIT
Stratification and Randomisation
Arm A: carbon ion RT (63 Gy E ± 5%, fractionation 4-6 × 3.0 Gy E)
Arm B: proton RT (72 Gy E ± 5%, fractionation 4-6 × 2.0 Gy E)
Treatment planning for particle therapy
Particle therapy
Follow-up