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Table 2 Dose constraints to organs at risk

From: Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study

OAR Dose constraints
Eyes, temporal lobes, salivary
glands, mandible and other
as low as possible
Optic nerves and chiasm ≤ 54 Gy
Brainstem ≤ 54 Gy with 1% of Volume allowed to receive >54 Gy, with Dmax ≤ 60 Gy
Brainstem center <50 Gy
Spinal cord ≤ 45 Gy with 1% of Volume allowed to receive >45 Gy, with Dmax ≤ 50 Gy