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Table 2 Dose constraints to organs at risk

From: Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study

OAR

Dose constraints

Eyes, temporal lobes, salivary

glands, mandible and other

as low as possible

Optic nerves and chiasm

≤ 54 Gy

Brainstem

≤ 54 Gy with 1% of Volume allowed to receive >54 Gy, with Dmax ≤ 60 Gy

Brainstem center

<50 Gy

Spinal cord

≤ 45 Gy with 1% of Volume allowed to receive >45 Gy, with Dmax ≤ 50 Gy