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Table 1 Risk group characterization

From: Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study

Low-risk

High-risk

Age > 30 years

Age ≤ 30 years

Male chordoma

Female chordoma

No OAR compression

Compression of OAR

Primary tumour

Recurrent tumor

Tumour size < 70 ml

Tumour size > 70 ml