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Table 1 Risk group characterization

From: Randomised trial of proton vs. carbon ion radiation therapy in patients with chordoma of the skull base, clinical phase III study HIT-1-Study

Low-risk High-risk
Age > 30 years Age ≤ 30 years
Male chordoma Female chordoma
No OAR compression Compression of OAR
Primary tumour Recurrent tumor
Tumour size < 70 ml Tumour size > 70 ml