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Figure 7 | BMC Cancer

Figure 7

From: Improved prognostic classification of breast cancer defined by antagonistic activation patterns of immune response pathway modules

Figure 7

Novel prognostic subtypes in ER- and ER+ breast cancer. A) & B) Kaplan Meier DMFS curves for dichotomised pathway activity levels, for IL12 and TGFB, in ER- breast cancer (Set1). C) Corresponding Kaplan Meier curve for the four subtypes stratified according to up/down activity of the two pathways. Hazard ratio refers to the IL12up-TGFBdn subtype relative to the rest. D) Independent validation in the test cohort (Set2). E) & F) Kaplan Meier DMFS curves for dichotomised pathway activity levels, for MYC and RAS, in ER+ breast cancer (Set1). G) Corresponding Kaplan Meier curve for the four subtypes stratified according to up/down activity of the two pathways. Hazard ratio refers to the MYCup-RASup subtype relative to the rest. H) Independent validation in the test cohort (Set2).

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