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Table 5 Independent Predictors of Mild to Severe Tricuspid or Pulmonary Regurgitation*

From: Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors

 

Univariate Analysis†

P-value

Multivariate Analysis

P-value

CCN2 ≥ 86 μg/L‡

5.45 [1.91;15.57]

0.002

7.76 [1.71;35.28]

0.008

Age ≥ 67 years

7.20 [2.27;22.80]

0.001

15.48 [3.00;79.89]

0.001

No. mets ≥ 9§

3.55 [1.27;9.23]

0.02

4.56 [1.06;19.63]

0.04

Duration ≥ 46 mos||

3.70 [1.34;10.21]

0.01

  

Carcinoid syndrome¶

7.24 [1.41, 37.26]

0.02

  
  1. *Logistic regression. †Results given as odds ratio (OR) with 95% confidence interval. ‡Connective tissue growth factor. §Number of liver metastases. ||Duration of illness in months. ¶Defined as flushing and/or diarrhea.