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Table 1 Clinical and Tumor Characteristics

From: Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors

Characteristic*

Normal/mildly

Reduced RV Function† (n = 36)

Reduced RV

Function

(n = 33)

P-value

No/minimal

TR/PR‡

(n = 29)

Mild to Severe

TR/PR

(n = 40)

P-value

Gender

  

0.06

  

0.22

   Men

13 (36%)

20 (61%)

 

11 (38%)

22 (55%)

 

   Women

23 (64%)

13 (39%)

 

18 (62%)

18 (45%)

 

Age§

63 (36-81)

65 (33-83)

0.87

60 (36-75)

68 (33-83)

<0.001

Smoking

5 (15%)

9 (28%)

0.23

5 (17%)

9 (24%)

0.56

Illness duration (yrs)

3.4 (0.8-7.5)

5.1 (2.3-6.8)

0.33

2.3 (0.7-5.2)

5.3 (2.6-7.8)

0.01

1° tumor size (mm)

20 (15-27)

20 (15-30)

0.44

20 (16-30)

19 (15-29)

0.53

Carcinoid syndrome¶

30 (83%)

29 (88%)

0.74

21 (72%)

38 (95%)

0.01

Ki 67#

2% (0-10)

2.5% (1-25)

0.16

2% (1-10)

2% (0-25)

0.20

U-5HIAA**

6 (2-19)

19 (4-29)

0.08

7 (2-19)

10 (3-30)

0.21

CgA††

14 (6-24)

26 (12-82)

0.02

16 (6-37)

19 (9-79)

0.31

Liver metastases

30 (83%)

30 (91%)

0.48

27 (93%)

33 (83%)

0.29

   Size (mm) ‡‡

15 (7-19)

15 (13-25)

0.18

14 (9-19)

17 (11-24)

0.22

   Number

6 (1-12)

11 (6-20)

0.01

6 (1-10)

11 (5-20)

0.03

  1. *Results given as median (interquartile range) or n (%) unless otherwise specified. †Right ventricular function. ‡Tricuspid and/or pulmonary regurgitation. §Median (range). Maximal diameter of the primary tumor. ¶Defined as flushing and/or diarrhea. #Proliferation index given as median (range). **Urinary 5-hydroxyindoleacetic acid (normal 0.9-3.8 μmol/mmol creatinine). ††Chromogranin A (normal < 4 nmol/L). ‡‡Median maximal diameter.