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Table 2 Average absolute Z scores for genes from pathways and biologic functions associated with the development of bone metastases

From: Prioritizing genes associated with prostate cancer development

Function and gene categorya No. of genesb Absolute Z score (SE) ttest Degrees of freedom p value
TGF-β signaling 86 2.58 (0.34) 4.05 15,770 0.00005
Integrins 30 2.47 (0.35) 3.82 15,773 0.0001
AR signaling pathway 32 2.22 (0.34) 2.9 15,780 0.004
Components of EC matrix 64 2.11 (0.25) 3.41 15,812 0.0006
Cell adhesion 406 2.08 (0.09) 7.99 16,154 <10E-6
Wnt signaling pathway 29 2.06 (0.27) 2.13 15,777 0.03
Bone development 56 1.99 (0.24) 2.53 15,804 0.01
Collagens 40 1.76 (0.28) 1.07 15,759 0.28
Cadherins 23 1.35 (0.19) 0.61 15,767 0.54
  1. Abbreviations: SE, standard error; TFG-β, transforming growth factor beta; AR, androgen receptor; EC, extracellular
  2. aFunctions were defined according to the Gene Ontology database.
  3. bA list of genes for each pathway can be found in Additional file 2.