Skip to main content

Table 2 Average absolute Z scores for genes from pathways and biologic functions associated with the development of bone metastases

From: Prioritizing genes associated with prostate cancer development

Function and gene categorya

No. of genesb

Absolute Z score (SE)

ttest

Degrees of freedom

p value

TGF-β signaling

86

2.58 (0.34)

4.05

15,770

0.00005

Integrins

30

2.47 (0.35)

3.82

15,773

0.0001

AR signaling pathway

32

2.22 (0.34)

2.9

15,780

0.004

Components of EC matrix

64

2.11 (0.25)

3.41

15,812

0.0006

Cell adhesion

406

2.08 (0.09)

7.99

16,154

<10E-6

Wnt signaling pathway

29

2.06 (0.27)

2.13

15,777

0.03

Bone development

56

1.99 (0.24)

2.53

15,804

0.01

Collagens

40

1.76 (0.28)

1.07

15,759

0.28

Cadherins

23

1.35 (0.19)

0.61

15,767

0.54

  1. Abbreviations: SE, standard error; TFG-β, transforming growth factor beta; AR, androgen receptor; EC, extracellular
  2. aFunctions were defined according to the Gene Ontology database.
  3. bA list of genes for each pathway can be found in Additional file 2.