Prognostic factors for outcomes after whole-brain irradiation of brain metastases from relatively radioresistant tumors: a retrospective analysis

Table 3 Univariate analysis of local control.

	At 6 months	At 12 months
	(%)	(%)	P
Tumor type
Malignant melanoma	37	5
Renal cell carcinoma	41	22
Colorectal cancer	33	14	0.36
WBI schedule
5 × 4 Gy	42	0
10 × 3 Gy	20	4
15 × 3/20 × 2 Gy	53	30	<0.001
Age
≤ 62 years	42	13
≥ 63 years	31	18	0.63
Gender
Female	33	16
Male	39	14	0.32
Karnofsky Performance Score
< 70	12	0
≥ 70	50	23	<0.001
Number of metastases
1-3	60	28
≥4	18	0	<0.001
Extracerebral metastases
No	45	21
Yes	32	10	0.10
Interval from first diagnosis to WBI
≤ 24 months	37	10
≥ 25 months	37	19	0.44
RPA class
1	80	38
2	42	18
3	12	0	<0.001

ISSN: 1471-2407