Figure 4

Detection of VEGF, MMP2, TIMP2, and MVD. (A1) Tumor MMP2 activities. *P < 0.05, †P < 0.01 compared with control. (A2) Tumor MMP2 levels. *P < 0.05, †P < 0.01 compared with control. (B) Tumor TIMP2 levels. *P < 0.01, †P < 0.001 compared with control. (C) Tumor VEGF levels. *P < 0.05, †P < 0.01, ‡P < 0.001 compared with control. (D1) Representative CD34 immunostained intratumoral microvessels (original magnification, ×200) in control group (left) and in the SYY + IFN-α group (right), bar, 50 μm. (D2) Tumor microvessel density (MVD). *P < 0.001 compared with control. The bars indicate the means ± SD.