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Figure 6 | BMC Cancer

Figure 6

From: Chemokine-mediated distribution of dendritic cell subsets in renal cell carcinoma

Figure 6

Immunohistochemistry of chemokine and chemokine receptor expression in RCC. Tumour cells show moderate cytoplasmatic expression for MIP-3α (A, 400x). Expression of MIP-3β is observed by DCs localized within lymphocyte aggregates at the tumour infiltration border (B, 400x). SLC is expressed by lymphatic vessels (open arrows) and in addition by stromal cells (arrows) at the tumour infiltration border (C, 400x). CCR6 positive cells with dendritic morphology are randomly distributed between the tumour cells (D, 400x). Few CCR6 positive DCs can be observed within the lymphatic aggregates of the tumour border zone (arrows, E, 400x). Numerous CCR7+ cells are found within the lympoid aggregates (F, 400x).

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