Figure 7
From: Epigenetic inactivation of the NORE1gene correlates with malignant progression of colorectal tumors
Anti-apoptotic function of NORE1A and NORE1B. Effect of NORE1 expression on baseline and etoposide-induced apoptosis (A, B). Caco-2 cells were transfected with WT-NORE1A or WT-NORE1B and percentage of sub G1 phase was determined by flow cytometric analysis. Caco-2 cells transfected with WT-NORE1 were treated with etoposide (25 μM, 24 h). Effect of NORE1 knockdown on etoposide-induced apoptosis (C, D). HCT116 cells transfected with siNORE1 were treated with etoposide (25 μM, 24 h).